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Information Journal Paper

Title

Value and Safety of High Flow Oxygenation in the Treatment of Inpatient Asthma: A Randomized, Double-blind, Pilot Study

Pages

  615-623

Keywords

High-flow nasal cannula (HFNC) 

Abstract

 This study was aimed to compare the value and safety of high-flow nasal cannula (HFNC) and conventional oxygen therapy (COT) in patients with Asthma exacerbation. In this randomized double-blind study, forthy patients with moderate-to-severe Asthma exacerbations, aged 18 years or older were enrolled. Patients were randomly assigned to receive either HFNC or COT for 24 hours. Dyspnea scale, O2 saturation, spirometer indexes, respiratory and heart rate, and arterial blood gas (ABG) were compared within 2 and 24 hours of intervention. Dyspnea scale decreased significantly from 7. 58± 1. 04 to 6. 45± 0. 51 (p=0. 000), and from 7. 84± 1. 7 to 6. 89± 0. 9 (p=0. 049) within 2 hours in HFNC and COT groups, respectively. In the HFNC group, forced expiratory volume in one second (FEV1) was 1. 48 ± 0. 94 L at the time of admission and increased to 1. 61± 0. 66 L (p=0. 19) and 1. 82± 0. 92 L (p=0. 003) after 2 and 24 hours of experience, respectively. In addition, in the COT group, FEV1 increased from 1. 43± 0. 65 L to 1. 46± 0. 53 L and 1. 64± 0. 6 L in the respective time-points, (p=0. 071, 0. 079). PaO2 and O2 saturation increased significantly in both groups during the first 2 hours. Two patients in the HFNC group had the complaint of nasal irritation and the device-produced heat; while one patient in the COT group needed more respiratory care. HFNC could be a therapeutic option for Asthma exacerbation among adult patients after considering the patient’ s selection.

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    • Cite

    APA: Copy

    Raeisi, Sharare, FAKHARIAN, ATEFEH, GHORBANI, FARIBA, JAMAATI, HAMID REZA, & Mirenayat, Maryam Sadat. (2019). Value and Safety of High Flow Oxygenation in the Treatment of Inpatient Asthma: A Randomized, Double-blind, Pilot Study. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 18(6), 615-623. SID. https://sid.ir/paper/748809/en

    Vancouver: Copy

    Raeisi Sharare, FAKHARIAN ATEFEH, GHORBANI FARIBA, JAMAATI HAMID REZA, Mirenayat Maryam Sadat. Value and Safety of High Flow Oxygenation in the Treatment of Inpatient Asthma: A Randomized, Double-blind, Pilot Study. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2019;18(6):615-623. Available from: https://sid.ir/paper/748809/en

    IEEE: Copy

    Sharare Raeisi, ATEFEH FAKHARIAN, FARIBA GHORBANI, HAMID REZA JAMAATI, and Maryam Sadat Mirenayat, “Value and Safety of High Flow Oxygenation in the Treatment of Inpatient Asthma: A Randomized, Double-blind, Pilot Study,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 18, no. 6, pp. 615–623, 2019, [Online]. Available: https://sid.ir/paper/748809/en

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