COMPARISON OF THE EFFECTS OF ETHINYL ESTRADIOL AND GENISTEIN ON SERUM LIPIDS AND LIPOPROTEINS OF HYPERCHOLESTROLEMIC MALE RATS

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IRANMANESH SH.; AFROUZ T.; VAHDATI A.

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Journal: Physiology and Pharmacology Year:2006 | Volume:10 | Issue:2 Page(s): 159-164

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Title

COMPARISON OF THE EFFECTS OF ETHINYL ESTRADIOL AND GENISTEIN ON SERUM LIPIDS AND LIPOPROTEINS OF HYPERCHOLESTROLEMIC MALE RATS

Author(s)

IRANMANESH SH. | AFROUZ T. | VAHDATI A. | Issue Writer Certificate

Keywords

ESTROGENQ2

PHYTOESTROGENQ2

LIPIDS AND LIPOPROTEINQ3

RATQ3

Abstract

Introduction: ESTROGEN is one of the female sexhormones that in addition to its reproductive role, has favorable effects on the metabolism of blood LIPIDS AND LIPOPROTEINs and by this way decreases the coronary heart disease. On the other hand, phytoESTROGENs are phytochemical substances that have effects like ESTROGENs. Isoflavones, which the most important of them is genistein, are the most common form of phytoESTROGENs. In this research, the effects of one phytoESTROGENic compounds named genistein and one ESTROGENic compound named ethinyl estradiol were compaired. The purpose of this comparison was to study of replacement possibility of phytoESTROGENs in ERT period for elimination of side effects of ESTROGENic compound.Methods: First the RATs were fed for 2 months with high cholestrol diet (2% cholestrol, 0/5% cholic acid). After the first blood test ensured the hypercholestrolemic condition, the RATs were treated for 2 months with ethinyl estradiol and genistein besides of high cholestrol diet. After the end of the second period and serum preparation from the blood samples disignated total cholestrol, triglyceride, HDL, LDL and VDL were measured and the. Results were statistically analyzed.Results: According to the obtained results of the first period of experiment, the usage of high cholestrol diet caused meaningful increase in total cholestrol and LDL as it made RATs hypercholestrolemic. According to the results of second period of experiment, the usage of ethinyl estradiol reduced the level of serum total cholesterol and LDL of hypercholestrolemic RATs, that was because of the effect of ESTROGEN on increase of LDL catabolism. Whereas, it did not produce meaningful changes in triglyceride, HDL and VDL. Usage of genistein in isolated form had no benefical effect on blood LIPIDS AND LIPOPROTEINs, Because hypocholestrolemic property of isoflavone depends on matrix that is beside it.

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APA: Copy

IRANMANESH, SH., AFROUZ, T., & VAHDATI, A.. (2006). COMPARISON OF THE EFFECTS OF ETHINYL ESTRADIOL AND GENISTEIN ON SERUM LIPIDS AND LIPOPROTEINS OF HYPERCHOLESTROLEMIC MALE RATS. PHYSIOLOGY AND PHARMACOLOGY, 10(2), 159-164. SID. https://sid.ir/paper/74903/en

Vancouver: Copy

IRANMANESH SH., AFROUZ T., VAHDATI A.. COMPARISON OF THE EFFECTS OF ETHINYL ESTRADIOL AND GENISTEIN ON SERUM LIPIDS AND LIPOPROTEINS OF HYPERCHOLESTROLEMIC MALE RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2006;10(2):159-164. Available from: https://sid.ir/paper/74903/en

IEEE: Copy

SH. IRANMANESH, T. AFROUZ, and A. VAHDATI, “COMPARISON OF THE EFFECTS OF ETHINYL ESTRADIOL AND GENISTEIN ON SERUM LIPIDS AND LIPOPROTEINS OF HYPERCHOLESTROLEMIC MALE RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 10, no. 2, pp. 159–164, 2006, [Online]. Available: https://sid.ir/paper/74903/en

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