INVESTIGATION OF THE EFFECTS OF A NEW SYNTHETIC IRON NANOCHELATOR ON NEURONAL EXCITABILITY IN THE PRESENCE AND ABSENCE OF OXIDATIVE STRESS

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GHASEMI ZAHRA; FAKHARZADEH SAEEDEH; NAZARAN MOHAMMAD HASSAN; JANAHMADI MAHYAR

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Journal: Physiology and Pharmacology Year:2012 | Volume:16 | Issue:2 Page(s): 95-106

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Title

INVESTIGATION OF THE EFFECTS OF A NEW SYNTHETIC IRON NANOCHELATOR ON NEURONAL EXCITABILITY IN THE PRESENCE AND ABSENCE OF OXIDATIVE STRESS

Author(s)

GHASEMI ZAHRA | FAKHARZADEH SAEEDEH | NAZARAN MOHAMMAD HASSAN | JANAHMADI MAHYAR | Issue Writer Certificate

Keywords

IRON NANOCHELATORQ2

H2O2Q3

INTRACELLULAR RECORDINGQ3

NEURONAL EXCITABILITYQ3

ION CHANNELSQ2

Abstract

Introduction: Oxidative stress is one of the important pathologic factors involved in the pathogenesis of neurodegenerative diseases. Antioxidants as neutralizing agents of free radicals are one of the treatment options for these diseases and antioxidant agents that can pass through blood brain barrier have beneficial effects. In the present research, the antioxidant effect of a new IRON NANOCHELATOR on the electrophysiological characteristics of neural cells following H2O2–induced oxidative stress was investigated.Methods: INTRACELLULAR RECORDINGs were made under the current clamp condition on F1 cells of Helix aspersa. Effects of oxidant agent, H2O2 (1 mM), in the presence of the new IRON NANOCHELATOR at high (2.63 mM) and low (263mM) concentrations were assessed on the firing pattern and action potential parameters and were compared to the control condition.Results: Application of H2O2 led to a significant decrease in the firing pattern and AP amplitude and an increase in the time to peak compared with control condition. Addition of the antioxidant following H2O2 treatment increased these parameters and restored them to the control condition. On the other hand, effects of H2O2 on the electrical activity of cell were modulated when the antioxidant was used earlier.Conclusion: Based on the modulating effects of the new synthesized IRON NANOCHELATOR on verified action potential parameters in the presence of H2O2, it can be concluded that nanochelator probably exerts its antioxidant effects through the alterations of the function of ION CHANNELS.

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APA: Copy

GHASEMI, ZAHRA, FAKHARZADEH, SAEEDEH, NAZARAN, MOHAMMAD HASSAN, & JANAHMADI, MAHYAR. (2012). INVESTIGATION OF THE EFFECTS OF A NEW SYNTHETIC IRON NANOCHELATOR ON NEURONAL EXCITABILITY IN THE PRESENCE AND ABSENCE OF OXIDATIVE STRESS. PHYSIOLOGY AND PHARMACOLOGY, 16(2), 95-106. SID. https://sid.ir/paper/74911/en

Vancouver: Copy

GHASEMI ZAHRA, FAKHARZADEH SAEEDEH, NAZARAN MOHAMMAD HASSAN, JANAHMADI MAHYAR. INVESTIGATION OF THE EFFECTS OF A NEW SYNTHETIC IRON NANOCHELATOR ON NEURONAL EXCITABILITY IN THE PRESENCE AND ABSENCE OF OXIDATIVE STRESS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2012;16(2):95-106. Available from: https://sid.ir/paper/74911/en

IEEE: Copy

ZAHRA GHASEMI, SAEEDEH FAKHARZADEH, MOHAMMAD HASSAN NAZARAN, and MAHYAR JANAHMADI, “INVESTIGATION OF THE EFFECTS OF A NEW SYNTHETIC IRON NANOCHELATOR ON NEURONAL EXCITABILITY IN THE PRESENCE AND ABSENCE OF OXIDATIVE STRESS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 16, no. 2, pp. 95–106, 2012, [Online]. Available: https://sid.ir/paper/74911/en

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