EFFECT OF ACUTE ADMINISTRATION OF CISPLATIN ON MEMORY, MOTOR LEARNING, BALANCE AND EXPLORATIVE BEHAVIOURS IN RATS

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SHOJAEI AHDIYE; SHABANI MOHAMMAD; PILEVARIAN ASGHAR; PARSANIA SHAHRNAZ; RAZAVINASAB MOAZAMEHOSADAT

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Journal: Physiology and Pharmacology Year:2012 | Volume:16 | Issue:2 Page(s): 121-135

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Title

EFFECT OF ACUTE ADMINISTRATION OF CISPLATIN ON MEMORY, MOTOR LEARNING, BALANCE AND EXPLORATIVE BEHAVIOURS IN RATS

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Keywords

CISPLATINQ3

MOTOR ACTIVITYQ2

CEREBELLUMQ3

LEARNING AND MEMORYQ3

Abstract

Introduction: For some cancer survivors chemotherapy treatment is associated with lasting motor and cognitive impairments, long after treatment cessation. CISPLATIN as an anti-neoplastic agent is extremely toxic and can cause severe tissue damage. In the present study, we elucidated alteration in performance of hippocampus- and CEREBELLUM related behaviors following acute CISPLATIN treatment in male and female rats.Methods: Male and female wistar rats (120) were divided randomly into eight (two controls [saline] and 6 CISPLATIN) groups. CEREBELLUM- and hippocampus-related behavioral dysfunction in CISPLATIN-treated (5, 10 and 15 mg/kg/week for 1 week) rats were analyzed using hippocampus and CEREBELLUM- dependent function tasks (Morris Water Maze, Shuttle box, Rotarod and Open field).Results: Exposure to CISPLATIN impaired motor coordination in male and female rats in all doses. In open field test, the rearing frequency, total distance moved and velocity of both males and females were dramatically affected by exposure to CISPLATIN. In Morris water maze test, male and female rats that were trained one week after CISPLATIN injection showed significant memory deficits compared to the saline-treated rats.Conclusion: Hippocampal and CEREBELLUM functions of male and female rats were profoundly affected by exposure to CISPLATIN. No sex-difference was observed in the most measured variables.

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APA: Copy

SHOJAEI, AHDIYE, SHABANI, MOHAMMAD, PILEVARIAN, ASGHAR, PARSANIA, SHAHRNAZ, & RAZAVINASAB, MOAZAMEHOSADAT. (2012). EFFECT OF ACUTE ADMINISTRATION OF CISPLATIN ON MEMORY, MOTOR LEARNING, BALANCE AND EXPLORATIVE BEHAVIOURS IN RATS. PHYSIOLOGY AND PHARMACOLOGY, 16(2), 121-135. SID. https://sid.ir/paper/74913/en

Vancouver: Copy

SHOJAEI AHDIYE, SHABANI MOHAMMAD, PILEVARIAN ASGHAR, PARSANIA SHAHRNAZ, RAZAVINASAB MOAZAMEHOSADAT. EFFECT OF ACUTE ADMINISTRATION OF CISPLATIN ON MEMORY, MOTOR LEARNING, BALANCE AND EXPLORATIVE BEHAVIOURS IN RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2012;16(2):121-135. Available from: https://sid.ir/paper/74913/en

IEEE: Copy

AHDIYE SHOJAEI, MOHAMMAD SHABANI, ASGHAR PILEVARIAN, SHAHRNAZ PARSANIA, and MOAZAMEHOSADAT RAZAVINASAB, “EFFECT OF ACUTE ADMINISTRATION OF CISPLATIN ON MEMORY, MOTOR LEARNING, BALANCE AND EXPLORATIVE BEHAVIOURS IN RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 16, no. 2, pp. 121–135, 2012, [Online]. Available: https://sid.ir/paper/74913/en

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