THE MODULATORY ROLE OF GABA-B RECEPTORS OF THE SHELL PART OF NUCLEUS ACCUMBENS IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MORPHINE-SENSITIZED RATS

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RAFIEIRAD M.; SAHRAEI HEDAYAT; HAERI ROUHANI SEYED ALI; SEPEHRI HOURI; ALAVIAN DEHAGHANI S.F.; GHOSHOUNI H.; NOUROUZZADEH ALI

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Journal: Physiology and Pharmacology Year:2007 | Volume:11 | Issue:3 Page(s): 182-191

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Title

THE MODULATORY ROLE OF GABA-B RECEPTORS OF THE SHELL PART OF NUCLEUS ACCUMBENS IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MORPHINE-SENSITIZED RATS

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MORPHINE SENSITIZATIONQ3

GABAB RECEPTORQ3

BACLOFENQ3

CONDITIONED PLACE PREFERENCEQ4

RATQ4

Abstract

Introduction: Considering the important role of nucleus accumbens in drug reward, in the present study, the effect of intra-accumbens administration of GABABreceptor agonist and antagonist on the expression and acquisition of morphine-induced CONDITIONED PLACE PREFERENCE (CPP) in morphine-sensitized RATs was investigated.Methods: In a pilot study, different doses of morphine (0.5, 1, 2.5, 5 and 7.5 mg/kg) were administered to the morphine-naive animals in order to identify ineffective doses of the drug. Sensitization was induced by subcutaneous (s.c.) injection of morphine (5 mg/kg; once daily for 3 days) followed by five days resting. After the period of sensitization, on the day 9, place conditioning was induced using ineffective dose of morphine (1 mg/kg, s.c.). GABAB receptor agonist, BACLOFEN (1.5, 6 or 12 mg/rat)or GABAB receptor antagonist, CGP35348 (1.5, 6 or 12 mg/rat)were injected into the shell part of nucleus accumbens acutely 5 min before the test of CPP (expression of CPP) or 10 min before each injection of morphine (acquisition of CPP).Results: The results indicated that injections of BACLOFEN (1.5 and 12 mg/rat) educed the expression of morphine CPP in morphine-sensitized RATs. BACLOFEN (1.5 and 12 mg/rat) also reduced the acquisition of morphine CPP in morphine-sensitized RATs. Injections of CGP35348 (6 and 12 mg/rat) reduced the expression of morphine CPP in morphine-sensitized RATs. CGP35348 (6 mg/rat) administration also reduced the acquisition of morphine CPP in morphine-sensitized RATs.Conclusion: In conclusion, these results confirm the modulator role for GABAB receptors within the shell part of nucleus accumbens in the acquisition and expression of morphine-induced place conditioning in morphine-sensitized RATs.

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APA: Copy

RAFIEIRAD, M., SAHRAEI, HEDAYAT, HAERI ROUHANI, SEYED ALI, SEPEHRI, HOURI, ALAVIAN DEHAGHANI, S.F., GHOSHOUNI, H., & NOUROUZZADEH, ALI. (2007). THE MODULATORY ROLE OF GABA-B RECEPTORS OF THE SHELL PART OF NUCLEUS ACCUMBENS IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MORPHINE-SENSITIZED RATS. PHYSIOLOGY AND PHARMACOLOGY, 11(3), 182-191. SID. https://sid.ir/paper/74956/en

Vancouver: Copy

RAFIEIRAD M., SAHRAEI HEDAYAT, HAERI ROUHANI SEYED ALI, SEPEHRI HOURI, ALAVIAN DEHAGHANI S.F., GHOSHOUNI H., NOUROUZZADEH ALI. THE MODULATORY ROLE OF GABA-B RECEPTORS OF THE SHELL PART OF NUCLEUS ACCUMBENS IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MORPHINE-SENSITIZED RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2007;11(3):182-191. Available from: https://sid.ir/paper/74956/en

IEEE: Copy

M. RAFIEIRAD, HEDAYAT SAHRAEI, SEYED ALI HAERI ROUHANI, HOURI SEPEHRI, S.F. ALAVIAN DEHAGHANI, H. GHOSHOUNI, and ALI NOUROUZZADEH, “THE MODULATORY ROLE OF GABA-B RECEPTORS OF THE SHELL PART OF NUCLEUS ACCUMBENS IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MORPHINE-SENSITIZED RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 11, no. 3, pp. 182–191, 2007, [Online]. Available: https://sid.ir/paper/74956/en

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