THE EFFECT OF NIMESULIDE ON COXII EXPRESSION IN CENTRAL AND PERIPHERAL IMMUNE CELLS (MICROGLIA AND MACROPHAGE) IN A RAT MODEL OF NEUROPATHIC PAIN

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MOEINI ZANJANI T.; OSTAD S.N.; MOSAFA NARIMAN; AMINI NOUSHIN

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Journal: Physiology and Pharmacology Year:2007 | Volume:11 | Issue:3 Page(s): 228-237

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Title

THE EFFECT OF NIMESULIDE ON COXII EXPRESSION IN CENTRAL AND PERIPHERAL IMMUNE CELLS (MICROGLIA AND MACROPHAGE) IN A RAT MODEL OF NEUROPATHIC PAIN

Author(s)

MOEINI ZANJANI T. | OSTAD S.N. | MOSAFA NARIMAN | AMINI NOUSHIN | Issue Writer Certificate

Keywords

NIMESULIDEQ3

NEUROPATHIC PAINQ3

HYPERALGESIAQ3

ALLODYNIAQ3

COXIIQ3

Abstract

Introduction: NEUROPATHIC PAIN may be due to a primary insult to the peripheral or central nervous system. It seems that immune cells play an important role in the development and maintenance of chronic pain. NIMESULIDE, a highly selective CoxII inhibitor, effectively reduces HYPERALGESIA due to peripherally administration of inflammatory agents like formalin. In this study we have investigated the effect of NIMESULIDE on pain behavior and CoxII expression in macrophage and tnicroglial cells in NEUROPATHIC PAIN condition.Methods: Male Wistar rats (150-200 g) were divided into 5 different groups: 1) CCI + saline 2) Sham + saline (control), 3) CCI + NIMESULIDE (1.25, 2.5 or 5 mg/kg). NEUROPATHIC PAIN was induced using Bennet and Xie model. Warm water (42°C) for thermal HYPERALGESIA and Von Frey filaments for mechanical ALLODYNIA were respectively used as pain behavioral tests. Experiments were performed on day before and days 1, 3, 5, 7, 10 and 14 days post injury. At day 14 rats which received NIMESULIDE 5 mg/kg were killed and CoxII was assessed in macrophages and tnicroglial cells. Results: NIMESULIDE 2.5 and 5mg/kg reduced HYPERALGESIA and ALLODYNIA. NIMESULIDE 5 mg/kg also reduced Coxn expression in macrophages and tnicroglial cells compared to CCI + saline group.Conclusion: NIMESULIDE reduced HYPERALGESIA due to nerve inflammation. CoxII -induced PGs activates a wide range of immune cells like macrophages and tnicroglia. It seems that NIMESULIDE a highly selective CoxII inhibitor can reduce effectively NEUROPATHIC PAIN.

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APA: Copy

MOEINI ZANJANI, T., OSTAD, S.N., MOSAFA, NARIMAN, & AMINI, NOUSHIN. (2007). THE EFFECT OF NIMESULIDE ON COX_II EXPRESSION IN CENTRAL AND PERIPHERAL IMMUNE CELLS (MICROGLIA AND MACROPHAGE) IN A RAT MODEL OF NEUROPATHIC PAIN. PHYSIOLOGY AND PHARMACOLOGY, 11(3), 228-237. SID. https://sid.ir/paper/74958/en

Vancouver: Copy

MOEINI ZANJANI T., OSTAD S.N., MOSAFA NARIMAN, AMINI NOUSHIN. THE EFFECT OF NIMESULIDE ON COX_II EXPRESSION IN CENTRAL AND PERIPHERAL IMMUNE CELLS (MICROGLIA AND MACROPHAGE) IN A RAT MODEL OF NEUROPATHIC PAIN. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2007;11(3):228-237. Available from: https://sid.ir/paper/74958/en

IEEE: Copy

T. MOEINI ZANJANI, S.N. OSTAD, NARIMAN MOSAFA, and NOUSHIN AMINI, “THE EFFECT OF NIMESULIDE ON COX_II EXPRESSION IN CENTRAL AND PERIPHERAL IMMUNE CELLS (MICROGLIA AND MACROPHAGE) IN A RAT MODEL OF NEUROPATHIC PAIN,” PHYSIOLOGY AND PHARMACOLOGY, vol. 11, no. 3, pp. 228–237, 2007, [Online]. Available: https://sid.ir/paper/74958/en

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