THE EFFECT OF INTRANUCLEUS ACCUMBENS-SHELL INJECTION OF RETINOIC ACID ON SERUM LEVEL OF GLUCOSE, TRIGLYCERIDE, CHOLESTEROL, AND LIPOPROTEINS IN RATS

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SHOJAEI N.; POURABOULI IRAN; TAJALLI S.; ABBASNEZHAD M.

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Journal: Physiology and Pharmacology Year:2007 | Volume:10 | Issue:4 Page(s): 323-329

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Title

THE EFFECT OF INTRANUCLEUS ACCUMBENS-SHELL INJECTION OF RETINOIC ACID ON SERUM LEVEL OF GLUCOSE, TRIGLYCERIDE, CHOLESTEROL, AND LIPOPROTEINS IN RATS

Author(s)

SHOJAEI N. | POURABOULI IRAN | TAJALLI S. | ABBASNEZHAD M. | Issue Writer Certificate

Keywords

RETINOIC ACIDQ3

NUCLEUS ACCUMBENSQ3

GLUCOSEQ3

TRIGLYCERIDEQ3

CHOLESTEROLQ3

LIPOPROTEINSQ3

Abstract

Introduction: RETINOIC ACID (RA) is a retinoid metabolite derived from vitamin A, which affects many metabolic and developmental processes. RA plays roles in physiological and pharmacological processes through regulating transcription of specific target genes.Peripheral administration of RA into human and animals decreases food intake, body weight and causes changes in biochemical blood parameters. NUCLEUS ACCUMBENS (NA) regulates the metabolism through hypothalamus and autonomic nervous system .In this study we investigated the effect of RETINOIC ACID injection into NA on blood biochemical parameters such as GLUCOSE, TRIGLYCERIDE , CHOLESTEROL and LIPOPROTEINS level.Methods: Rats were anaesthetized by ketamin-xylazine (60mg/kg – 4mg/kg,ip) and implanted bilaterally by cannuli into the NUCLEUS ACCUMBENS shell (AP=1.7mm and LA=0,8mm from bregma, DM=5,6mm from the scale). After one week recovery period, RA (1,5, 3 or 6 mg ) was injected daily (volume= 0.5 ml) for 4 days. Then animals were decapitated and the blood samples were collected. Serum levels of GLUCOSE, TRIGLYCERIDE and CHOLESTEROL were measured by spectrophotometry using commercial kits.Results: Data showed that centrally injected RA in NUCLEUS ACCUMBENS caused decrement in serum level of CHOLESTEROL and HDL, but increased serum levels of GLUCOSE and TRIGLYCERIDE and didn’t change VLDL level.Conclusion: It seems that NUCLEUS ACCUMBENS shell RA receptors are effective on metabolic reactions and serum levels of metabolites..

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APA: Copy

SHOJAEI, N., POURABOULI, IRAN, TAJALLI, S., & ABBASNEZHAD, M.. (2007). THE EFFECT OF INTRANUCLEUS ACCUMBENS-SHELL INJECTION OF RETINOIC ACID ON SERUM LEVEL OF GLUCOSE, TRIGLYCERIDE, CHOLESTEROL, AND LIPOPROTEINS IN RATS. PHYSIOLOGY AND PHARMACOLOGY, 10(4), 323-329. SID. https://sid.ir/paper/74964/en

Vancouver: Copy

SHOJAEI N., POURABOULI IRAN, TAJALLI S., ABBASNEZHAD M.. THE EFFECT OF INTRANUCLEUS ACCUMBENS-SHELL INJECTION OF RETINOIC ACID ON SERUM LEVEL OF GLUCOSE, TRIGLYCERIDE, CHOLESTEROL, AND LIPOPROTEINS IN RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2007;10(4):323-329. Available from: https://sid.ir/paper/74964/en

IEEE: Copy

N. SHOJAEI, IRAN POURABOULI, S. TAJALLI, and M. ABBASNEZHAD, “THE EFFECT OF INTRANUCLEUS ACCUMBENS-SHELL INJECTION OF RETINOIC ACID ON SERUM LEVEL OF GLUCOSE, TRIGLYCERIDE, CHOLESTEROL, AND LIPOPROTEINS IN RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 10, no. 4, pp. 323–329, 2007, [Online]. Available: https://sid.ir/paper/74964/en

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