COVID-19 interactions with angiotensin-converting enzyme 2 (ACE2) and the kinin system; looking at a potential treatment

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TOLOUIAN RAMIN; ZUNUNI VAHED SEPIDEH; GHIYASVAND SHAHRAM; Tolouian Audrey; ARDALAN MOHAMMAD REZA

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Journal Paper

Paper Information

Journal: JOURNAL OF RENAL INJURY PREVENTION Year:2020 | Volume:9 | Issue:2 Page(s): 0-0

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Title

COVID-19 interactions with angiotensin-converting enzyme 2 (ACE2) and the kinin system; looking at a potential treatment

Author(s)

Keywords

COVID-19

SARS-CoV

Bradykinin

Lung injury

ACE2

Coronavirus

Acute respiratory distress syndrome

Angiotensin converting enzyme2

Abstract

The novel Coronavirus disease 2019 (COVID-19) is a rapidly expanding infection around the world. The world Health Organization (WHO) in March 2020 announced the Coronavirus pandemic. This infection causes many deaths on daily basis. Therapeutic options are currently limited. It is revealed that COVID-19 binds to human angiotensin-converting enzyme 2 (ACE2) to enter the host cells. One of the activities of ACE2 is hydrolyzing the active Bradykinin metabolite [des-Arg973] BK (DABK). A decreased activity or reducing expression of ACE2 by the virus impairs the inactivation of DABK. This enhances its signaling through the Bradykinin B1 receptor (BKB1R) and could lead to fluid extravasation and leukocyte recruitment to the lung. Targeting the Bradykinin system by either blocking the Bradykinin production or blocking Bradykinin receptors may open a new potential therapeutic window for the treatment of COVID-19 induced Acute respiratory distress syndrome (ARDS) particularly before patients enter the irreversible stages.

Cites

Measures of Mortality in Coronavirus (COVID-19) Compared with SARS and MERS

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APA: Copy

TOLOUIAN, RAMIN, ZUNUNI VAHED, SEPIDEH, GHIYASVAND, SHAHRAM, Tolouian, Audrey, & ARDALAN, MOHAMMAD REZA. (2020). COVID-19 interactions with angiotensin-converting enzyme 2 (ACE2) and the kinin system; looking at a potential treatment. JOURNAL OF RENAL INJURY PREVENTION, 9(2), 0-0. SID. https://sid.ir/paper/749668/en

Vancouver: Copy

TOLOUIAN RAMIN, ZUNUNI VAHED SEPIDEH, GHIYASVAND SHAHRAM, Tolouian Audrey, ARDALAN MOHAMMAD REZA. COVID-19 interactions with angiotensin-converting enzyme 2 (ACE2) and the kinin system; looking at a potential treatment. JOURNAL OF RENAL INJURY PREVENTION[Internet]. 2020;9(2):0-0. Available from: https://sid.ir/paper/749668/en

IEEE: Copy

RAMIN TOLOUIAN, SEPIDEH ZUNUNI VAHED, SHAHRAM GHIYASVAND, Audrey Tolouian, and MOHAMMAD REZA ARDALAN, “COVID-19 interactions with angiotensin-converting enzyme 2 (ACE2) and the kinin system; looking at a potential treatment,” JOURNAL OF RENAL INJURY PREVENTION, vol. 9, no. 2, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/749668/en

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