Efficacy and Safety of rituximab in children with difficult-to-treat nephrotic syndrome; a systematic review

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AZARFAR ANOUSH; RAVANSHAD YALDA; Mehrad Majd Hassan; Badiei Aval Shapour; Nastarani sanaz; EMADZADEH MARYAM; KHAZAEI MAHMOODREZA; FAZEL MOJTABA; Azimi Behnam

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Journal: JOURNAL OF RENAL INJURY PREVENTION Year:2018 | Volume:7 | Issue:4 Page(s): 307-313

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Title

Efficacy and Safety of rituximab in children with difficult-to-treat nephrotic syndrome; a systematic review

Author(s)

Keywords

Rituximab

Nephrotic syndrome

Children

Treatment

Proteinuria

Hypoalbuminemia

Hypercoagulability

Dyslipidemia

Abstract

To date, several studies have been done on efficacy and safety of drugs in Children with refractory Nephrotic syndrome (NS). Rituximab (RTX) might be a hopeful Treatment for this syndrome. However, the long-term effects and cost-effectiveness of RTX Treatment were not fully assessed. This study aims to do a systematic review about the efficacy and safety of RTX in Children with difficult-to-treat NS. For this research, an electronic literature search was conducted to identify appropriate investigations. The search term was (“ Nephrotic syndrome” or “ minimal change disease” or “ focal segmental glomerulosclerosis” or membranous) and (‘ ‘ Rituximab’ ’ or ‘ ‘ CD20’ ’ ). We included all randomized trials and observational studies about using RTX in Children with difficult-to-treat NS. Two independent reviewers extracted data from the papers according to the selection criteria. Eligible studies were included in this systematic review. The literature search and reference mining yielded 919 potential relevant papers. We removed 340 articles because of duplication. We also excluded 513 papers after reviewing the titles and abstracts. Finally, 17 studies were included in the systematic review. Efficacy of RTX in Children with NS in most of the studies was assessed with relapse-free survival or complete remission rates. Acknowledging the limitations of the study due to the size and nature of the studies included, our systematic review shows that RTX was effective in the Treatment of refractory NS in Children, and it could reduce the use of steroid and immunosuppressants. However, further large randomized trials are suggested.

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APA: Copy

AZARFAR, ANOUSH, RAVANSHAD, YALDA, Mehrad Majd, Hassan, Badiei Aval, Shapour, Nastarani, sanaz, EMADZADEH, MARYAM, KHAZAEI, MAHMOODREZA, FAZEL, MOJTABA, & Azimi, Behnam. (2018). Efficacy and Safety of rituximab in children with difficult-to-treat nephrotic syndrome; a systematic review. JOURNAL OF RENAL INJURY PREVENTION, 7(4), 307-313. SID. https://sid.ir/paper/749680/en

Vancouver: Copy

AZARFAR ANOUSH, RAVANSHAD YALDA, Mehrad Majd Hassan, Badiei Aval Shapour, Nastarani sanaz, EMADZADEH MARYAM, KHAZAEI MAHMOODREZA, FAZEL MOJTABA, Azimi Behnam. Efficacy and Safety of rituximab in children with difficult-to-treat nephrotic syndrome; a systematic review. JOURNAL OF RENAL INJURY PREVENTION[Internet]. 2018;7(4):307-313. Available from: https://sid.ir/paper/749680/en

IEEE: Copy

ANOUSH AZARFAR, YALDA RAVANSHAD, Hassan Mehrad Majd, Shapour Badiei Aval, sanaz Nastarani, MARYAM EMADZADEH, MAHMOODREZA KHAZAEI, MOJTABA FAZEL, and Behnam Azimi, “Efficacy and Safety of rituximab in children with difficult-to-treat nephrotic syndrome; a systematic review,” JOURNAL OF RENAL INJURY PREVENTION, vol. 7, no. 4, pp. 307–313, 2018, [Online]. Available: https://sid.ir/paper/749680/en

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