THE ROLE OF HIPPOCAMPAL ADENOSINE A1 RECEPTORS IN SEIZURES ELICITED FROM ELECTRICAL STIMULATION OF AMYGDALA

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ALASVAND M.; MIRNAJAFIZADEH S.J.; FATH ELAHI Y.; MORTAZAVI S.M.; PALIZVAN M.R.

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Journal: Physiology and Pharmacology Year:2002 | Volume:5 | Issue:2 Page(s): 121-132

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Title

THE ROLE OF HIPPOCAMPAL ADENOSINE A1 RECEPTORS IN SEIZURES ELICITED FROM ELECTRICAL STIMULATION OF AMYGDALA

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Keywords

EPILEPSYQ3

ADENOSINEQ3

AMYGDALAQ4

HIPPOCAMPUSQ3

KINDLINGQ3

Abstract

In this study, the role of ADENOSINE A1 receptors of CA1region of the HIPPOCAMPUS was investigated on AMYGDALA kindled seizures in rats. A 3-polar electrode and two guide cannules were implanted in AMYGDALA and CA1 region of HIPPOCAMPUS respectively. The results showed that in kindled animals, bilateral injection of N6-Cyclohexyladenosine (CHA), an ADENOSINE A1 receptor agonist 5, 15, and 60 min after stimulation at doses of 0.1, 1, and 10 µM into the CA1 region significantly decreased the duration of after-discharge and stage 5 of seizure and increased the latency of stage 4, but there was no changes in seizure stage. Also, bilateral injection of 1, 3-dimethy 1-8-cyclopenthylxanthine (CPT), an ADENOSINE A1 receptor antagonist at doses of 0.5 and 1 µM into the CA1 region did not produce any changes in the seizure parameters. Intrahippocampal pretreatment of CPT (1 µM) before CHA treatment (0.1 and 1µM) significantly reduced the effects of CHA on seizure parameters. Therefore, it may be concluded that CA1 region of the HIPPOCAMPUS plays an important role in spreading of seizure spikes from AMYGDALA to other brain regions and activation of ADENOSINE A1 receptors in this region participates in anticonvulsant effects of ADENOSINE agonists.

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APA: Copy

ALASVAND, M., MIRNAJAFIZADEH, S.J., FATH ELAHI, Y., MORTAZAVI, S.M., & PALIZVAN, M.R.. (2002). THE ROLE OF HIPPOCAMPAL ADENOSINE A1 RECEPTORS IN SEIZURES ELICITED FROM ELECTRICAL STIMULATION OF AMYGDALA. PHYSIOLOGY AND PHARMACOLOGY, 5(2), 121-132. SID. https://sid.ir/paper/74979/en

Vancouver: Copy

ALASVAND M., MIRNAJAFIZADEH S.J., FATH ELAHI Y., MORTAZAVI S.M., PALIZVAN M.R.. THE ROLE OF HIPPOCAMPAL ADENOSINE A1 RECEPTORS IN SEIZURES ELICITED FROM ELECTRICAL STIMULATION OF AMYGDALA. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2002;5(2):121-132. Available from: https://sid.ir/paper/74979/en

IEEE: Copy

M. ALASVAND, S.J. MIRNAJAFIZADEH, Y. FATH ELAHI, S.M. MORTAZAVI, and M.R. PALIZVAN, “THE ROLE OF HIPPOCAMPAL ADENOSINE A1 RECEPTORS IN SEIZURES ELICITED FROM ELECTRICAL STIMULATION OF AMYGDALA,” PHYSIOLOGY AND PHARMACOLOGY, vol. 5, no. 2, pp. 121–132, 2002, [Online]. Available: https://sid.ir/paper/74979/en

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