EFFECT OF REVERSIBLE INHIBITION OF HIPPOCAMPAL CAT REGION BY LIDOCAINE ON AMYGDALA KINDLED SEIZURES IN RATS

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MORTAZAVI S.M.; MIRNAJAFIZADEH S.J.; FATH ELAHI Y.; ALLASVAND M.; PALIZVAN M.R.

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Journal: Pathobiology Research Year:2002 | Volume:4 | Issue:2 Page(s): 181-188

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Title

EFFECT OF REVERSIBLE INHIBITION OF HIPPOCAMPAL CAT REGION BY LIDOCAINE ON AMYGDALA KINDLED SEIZURES IN RATS

Author(s)

Keywords

EPILEPSYQ3

SEIZUREQ3

KINDLINGQ3

HIPPOCAMPUSQ3

AMYGDALAQ4

LIDOCAINEQ3

Abstract

In this study the role of CA1 region of dorsal HIPPOCAMPUS on amygdaloid kindled SEIZUREs was investigated by bilateral microinjection of LIDOCAINE into the HIPPOCAMPUS.All animals were implanted with a tripolar electrode into the basolateral AMYGDALA and 2 guide cannulae into the CA1 region of the HIPPOCAMPUS of the both hemispheres. Animals were kindled by daily electrical stimulation of the AMYGDALA, then divided into six groups. In groups 1-3, 1% LIDOCAINE was infused into the HIPPOCAMPUS (1µ 1/2min) and animals were stimulated at 5, 15 and 30 min after the injection and SEIZURE parameters were measured. In groups 4-6, 2% LIDOCAINE was infused into the HIPPOCAMPUS (1µ 1/2min) and the SEIZURE parameters were measured by the same manner as in groups 1-3. In all groups, 24h before LIDOCAINE injection, saline was injected (1µ 1/2min) and the parameters were recorded as control. Results showed that afterdischarge duration was reduced at 5 min after the LIDOCAINE (1% and 2%) injection. The stage 5 SEIZURE duration was also decreased at 5 and 15 min after the 2% LIDOCAINE injection. Thus, it may be suggested that in the AMYGDALA KINDLING, the activity of neurons of the hippocampal CA1 region has a role in the spreading of SEIZURE spikes from the AMYGDALA to the other brain region(s) and reduction of this activity results in the decrease of SEIZURE severity.

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APA: Copy

MORTAZAVI, S.M., MIRNAJAFIZADEH, S.J., FATH ELAHI, Y., ALLASVAND, M., & PALIZVAN, M.R.. (2002). EFFECT OF REVERSIBLE INHIBITION OF HIPPOCAMPAL CAT REGION BY LIDOCAINE ON AMYGDALA KINDLED SEIZURES IN RATS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 4(2), 181-188. SID. https://sid.ir/paper/81339/en

Vancouver: Copy

MORTAZAVI S.M., MIRNAJAFIZADEH S.J., FATH ELAHI Y., ALLASVAND M., PALIZVAN M.R.. EFFECT OF REVERSIBLE INHIBITION OF HIPPOCAMPAL CAT REGION BY LIDOCAINE ON AMYGDALA KINDLED SEIZURES IN RATS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2002;4(2):181-188. Available from: https://sid.ir/paper/81339/en

IEEE: Copy

S.M. MORTAZAVI, S.J. MIRNAJAFIZADEH, Y. FATH ELAHI, M. ALLASVAND, and M.R. PALIZVAN, “EFFECT OF REVERSIBLE INHIBITION OF HIPPOCAMPAL CAT REGION BY LIDOCAINE ON AMYGDALA KINDLED SEIZURES IN RATS,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 4, no. 2, pp. 181–188, 2002, [Online]. Available: https://sid.ir/paper/81339/en

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