THE EFFECT OF ORAL DEFEROXAMINE ON URINARY IRON EXCRETION IN IRON-OVERLOADED RATS

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JORJANI M.; TOLIAT T.; SHEIKH VEYSI M.

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Journal: Physiology and Pharmacology Year:2002 | Volume:5 | Issue:2 Page(s): 133-140

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Title

THE EFFECT OF ORAL DEFEROXAMINE ON URINARY IRON EXCRETION IN IRON-OVERLOADED RATS

Author(s)

JORJANI M. | TOLIAT T. | SHEIKH VEYSI M. | Issue Writer Certificate

Keywords

ORAL DEFEROXAMINEQ4

URINARY IRON EXCRETIONQ4

CHITOSANQ3

RATQ3

Abstract

Although parenteral administration of deferoxamine is the most effective treatment for acute or chronic toxicity of iron overload states, but due to its poor absorption through gastrointestinal tract, it is not appropriate to use it through oral route. In this study, urinary excretion of iron by ORAL DEFEROXAMINE solution was studied in male adult RATs. Oral administration of deferoxamine (500 mg/Kg) in iron-overloaded animals leads to URINARY IRON EXCRETION by a factor of 33% compared .to parenteral admimnistration of deferoxamine (100 mg/Kg; i.p.). The RATe of iron excretion reached to 88% when deferoxamine was injected directly into the duodenum and the gastric acid hydrolysis was avoided.Addition of 0.5% CHITOSAN to ORAL DEFEROXAMINE solution did not produce any significant change in iron excretion. However CHITOSAN at a concentration of 1.5% caused a significant increase in absorption of deferoxamine within duodenum, and iron excretion was about 99% as effective as the amount obtained by the parenteral deferoxamine. Based on these results, gastric acid has a significant degrading effect on deferoxamine. Therefore, it is suggested that coated formulations should be used for oral administration of this effective drug in treatment of iron poisoning.

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APA: Copy

JORJANI, M., TOLIAT, T., & SHEIKH VEYSI, M.. (2002). THE EFFECT OF ORAL DEFEROXAMINE ON URINARY IRON EXCRETION IN IRON-OVERLOADED RATS. PHYSIOLOGY AND PHARMACOLOGY, 5(2), 133-140. SID. https://sid.ir/paper/74980/en

Vancouver: Copy

JORJANI M., TOLIAT T., SHEIKH VEYSI M.. THE EFFECT OF ORAL DEFEROXAMINE ON URINARY IRON EXCRETION IN IRON-OVERLOADED RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2002;5(2):133-140. Available from: https://sid.ir/paper/74980/en

IEEE: Copy

M. JORJANI, T. TOLIAT, and M. SHEIKH VEYSI, “THE EFFECT OF ORAL DEFEROXAMINE ON URINARY IRON EXCRETION IN IRON-OVERLOADED RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 5, no. 2, pp. 133–140, 2002, [Online]. Available: https://sid.ir/paper/74980/en

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