ELECTROPHYSIOLOGICAL AND HISTOLOGICAL STUDY OF LYSOLECITHIN-INDUCED LOCAL DEMYELINATION IN ADULT MICE OPTIC CHIASM

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POURABDOLHOSSEIN FERESHTEH; MOZAFARI SABAH; JAVAN MOHAMMAD; MIRNAJAFI ZADEH JAVAD; AHMADIANI ABOLHASSAN

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Journal: Physiology and Pharmacology Year:2011 | Volume:14 | Issue:4 Page(s): 325-336

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Title

ELECTROPHYSIOLOGICAL AND HISTOLOGICAL STUDY OF LYSOLECITHIN-INDUCED LOCAL DEMYELINATION IN ADULT MICE OPTIC CHIASM

Author(s)

Keywords

LYSOLECITHINQ3

DEMYELINATIONQ3

MYELIN REPAIRQ3

OPTIC CHIASMQ3

VISUAL EVOKED POTENTIAL (VEP)Q3

MOUSEQ3

Abstract

Introduction: DEMYELINATION is one of the main causes of neurological disability. It is the end product of numerous pathological processes, multiple sclerosis (MS) being the most common cause. More than 70% of the MS patients suffer from optic disturbances. This disease commonly affects the optic pathway, particularly the optic nerves and chiasm. Several attempts have been made to produce a suitable model of DEMYELINATION in optic apparatus up to now.Methods: Local DEMYELINATION model was generated using direct injection of LYSOLECITHIN (LPC) into the OPTIC CHIASM of C57/BLJ6 mice without any undesirable distributions of gliotoxin into other brain structures. Histological and electrophysiological assessments of the processes of DEMYELINATION and remyelination in the animal model were done with specific myelin staining and visual evoked potential (VEP) recordings.Results: In this study, both electrophysiological and histological results demonstrated that maximum level of DEMYELINATION was observed on day 7 post lesion and an incomplete yet significant remyelination took place on day 14 post lesion.Conclusion: Results showed a relatively rapid endogenous MYELIN REPAIR in mice OPTIC CHIASM. Furthermore, this report might offer a new tool to address possible involvement of new origins of myelin-forming cells and subsequently their manipulation to promote MYELIN REPAIR in the adult central nervous system.

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APA: Copy

POURABDOLHOSSEIN, FERESHTEH, MOZAFARI, SABAH, JAVAN, MOHAMMAD, MIRNAJAFI ZADEH, JAVAD, & AHMADIANI, ABOLHASSAN. (2011). ELECTROPHYSIOLOGICAL AND HISTOLOGICAL STUDY OF LYSOLECITHIN-INDUCED LOCAL DEMYELINATION IN ADULT MICE OPTIC CHIASM. PHYSIOLOGY AND PHARMACOLOGY, 14(4), 325-336. SID. https://sid.ir/paper/74989/en

Vancouver: Copy

POURABDOLHOSSEIN FERESHTEH, MOZAFARI SABAH, JAVAN MOHAMMAD, MIRNAJAFI ZADEH JAVAD, AHMADIANI ABOLHASSAN. ELECTROPHYSIOLOGICAL AND HISTOLOGICAL STUDY OF LYSOLECITHIN-INDUCED LOCAL DEMYELINATION IN ADULT MICE OPTIC CHIASM. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2011;14(4):325-336. Available from: https://sid.ir/paper/74989/en

IEEE: Copy

FERESHTEH POURABDOLHOSSEIN, SABAH MOZAFARI, MOHAMMAD JAVAN, JAVAD MIRNAJAFI ZADEH, and ABOLHASSAN AHMADIANI, “ELECTROPHYSIOLOGICAL AND HISTOLOGICAL STUDY OF LYSOLECITHIN-INDUCED LOCAL DEMYELINATION IN ADULT MICE OPTIC CHIASM,” PHYSIOLOGY AND PHARMACOLOGY, vol. 14, no. 4, pp. 325–336, 2011, [Online]. Available: https://sid.ir/paper/74989/en

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