مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

Effect of L-carnitine on Troponin, IL-6 and HS– CRP levels after Coronary Artery Bypass Graft Surgery

Pages

  41-48

Abstract

 Background: L-carnitine seems to be able to prevent complications after heart surgery using Cardiopulmonary bypass (CPB) and the adverse effects of pump usage. This study aimed to evaluates the effects of L-carnitine on cardiac biomarkers and operation characteristics after coronary artery bypass graft (CABG) surgery. Methods and materials: In this randomized triple-blinded, sixty patients undergoing elective CABG surgery were divided into three equal groups to receive 2gr oral L-carnitine (group A), 5gr oral L-carnitine (group B) and placebo (group C) 2 hours before surgery. IL-6, creatinine, and high sensitivity C-reactive protein (HS– CRP) levels, CK-MB, cardiac Troponin and inotrope administration in ICU or after CPB were recorded for all patients at baseline levels and at 8 or 24 hours postoperatively. Results: There was an evidence of a significant difference in CPK-MB level and number of red blood cell packed used in group A was lower than group C (p<0. 05). The cardiac Troponin level 8 hours after surgery significantly decreased in two treatment groups in comparison to group C (p<0. 05). The need for inotropic support after weaning from CPB, in B group was statistically higher than C group (p=0. 021). Conclusion: Although L-carnitine adjunct therapy appears not to be associated with IL-6 and HS– CRP levels, it had beneficial effects on cardiac Troponin and CPK-MB levels.

Cites

References

Cite

APA: Copy

KHALILI, ALI, Fani, Kamal, NAZIRI, MAHDYIEH, FOROUGHI, MAHNOOSH, DASTAN, FARZANEH, DABBAGH, ALI, JELVEHMOGHADAM, HOSSEINALI, & JAHANGIRIFARD, ALIREZA. (2019). Effect of L-carnitine on Troponin, IL-6 and HS– CRP levels after Coronary Artery Bypass Graft Surgery. JOURNAL OF CELLULAR AND MOLECULAR ANESTHESIA, 4(2), 41-48. SID. https://sid.ir/paper/750098/en

Vancouver: Copy

KHALILI ALI, Fani Kamal, NAZIRI MAHDYIEH, FOROUGHI MAHNOOSH, DASTAN FARZANEH, DABBAGH ALI, JELVEHMOGHADAM HOSSEINALI, JAHANGIRIFARD ALIREZA. Effect of L-carnitine on Troponin, IL-6 and HS– CRP levels after Coronary Artery Bypass Graft Surgery. JOURNAL OF CELLULAR AND MOLECULAR ANESTHESIA[Internet]. 2019;4(2):41-48. Available from: https://sid.ir/paper/750098/en

IEEE: Copy

ALI KHALILI, Kamal Fani, MAHDYIEH NAZIRI, MAHNOOSH FOROUGHI, FARZANEH DASTAN, ALI DABBAGH, HOSSEINALI JELVEHMOGHADAM, and ALIREZA JAHANGIRIFARD, “Effect of L-carnitine on Troponin, IL-6 and HS– CRP levels after Coronary Artery Bypass Graft Surgery,” JOURNAL OF CELLULAR AND MOLECULAR ANESTHESIA, vol. 4, no. 2, pp. 41–48, 2019, [Online]. Available: https://sid.ir/paper/750098/en

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