STUDY OF THE EFFECTS OF INTRA-NUCLEUS ACCUMBENS SHELL INJECTIONS OF ALCOHLIC EXTRACT OF CROCUS SATIVUS ON THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN RATS

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MOJABI N.A.S.; EYDI AKRAM; KAMALINEZHAD MOHAMMAD; KHAMSEH F.; KHOUSHBATEN A.; NOUROUZZADEH ALI; ZIGHEYMAT F.; SAHRAEI HEDAYAT

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Journal: Physiology and Pharmacology Year:2008 | Volume:12 | Issue:2 Page(s): 121-128

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Title

STUDY OF THE EFFECTS OF INTRA-NUCLEUS ACCUMBENS SHELL INJECTIONS OF ALCOHLIC EXTRACT OF CROCUS SATIVUS ON THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN RATS

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Keywords

MORPHINEQ3

CONDITIONED PLACE PREFERENCEQ4

RATSQ3

SAFFRON EXTRACTQ3

Abstract

Introduction: Previous studies have shown the effects of water extract of Crocus sativus on the euphoric and behavioral properties of MORPHINE in mice. In the present study, the effects of intra-accumbal administration of alcohol extract of Crocus sativus stigma on the acquisition and expression of MORPHINE-induced CONDITIONED PLACE PREFERENCE (CPP) in male Wistar RATS (250-300 g) were investigated.Methods: This study was conducted on 78 male RATS that were divided in 13 groups (n =6 each group). In a pilot study, different doses of MORPHINE (0.5, 1, 2.5, 5, 7.5 and 10 mg/kg) were injected to the animals for evaluation of the drug's ability to induce place preference. In the second phase of the experiments, the extract of the C. sativus (1, 5 and 10 mg/rat), was administered into the nucleus accumbens shell during or after induction of MORPHINE CPP. Then, CPP was tested in the animals. One-way Analysis of Variance (ANOVA) was preformed for statistical procedure. Results: Administration of MORPHINE (0.5, 1,5,7.5 and 10mg/kg), increased the time spent in the compartment paired with MORPHINE (i.e. CONDITIONED PLACE PREFERENCE-CPP) (P<0.05). This increase reached significance at the dose of 10 mglkg. Injection of the same doses of the extract (1,5 and 10 mg/rat) 5 min before MORPHINE (10 mg/kg) administration, caused a decrease in the time spent in drug-paired side in doses 5 and 10 mg/rat of the extract (P < 0.0001). In addition, injection of the plant extract (1,5 and 10 mg/rat) in to the shell part of nucleus accumbens in the test day to the animals that received MORPHINE (10 mg/kg) in the conditioning days decreased the expression of MORPHINE CPP in the animals. This effect was statistically significant for doses 5 and 10 mg/rat of the extract (P<0.0001). Conclusion: It may be concluded that intra-acumens shell compartment injection of the alcoholic extract of C sativus can inhibit the acquisition and expression of MORPHINE-induced CPP and then shift it to the aversive state in RATS.

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APA: Copy

MOJABI, N.A.S., EYDI, AKRAM, KAMALINEZHAD, MOHAMMAD, KHAMSEH, F., KHOUSHBATEN, A., NOUROUZZADEH, ALI, ZIGHEYMAT, F., & SAHRAEI, HEDAYAT. (2008). STUDY OF THE EFFECTS OF INTRA-NUCLEUS ACCUMBENS SHELL INJECTIONS OF ALCOHLIC EXTRACT OF CROCUS SATIVUS ON THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN RATS. PHYSIOLOGY AND PHARMACOLOGY, 12(2), 121-128. SID. https://sid.ir/paper/75014/en

Vancouver: Copy

MOJABI N.A.S., EYDI AKRAM, KAMALINEZHAD MOHAMMAD, KHAMSEH F., KHOUSHBATEN A., NOUROUZZADEH ALI, ZIGHEYMAT F., SAHRAEI HEDAYAT. STUDY OF THE EFFECTS OF INTRA-NUCLEUS ACCUMBENS SHELL INJECTIONS OF ALCOHLIC EXTRACT OF CROCUS SATIVUS ON THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2008;12(2):121-128. Available from: https://sid.ir/paper/75014/en

IEEE: Copy

N.A.S. MOJABI, AKRAM EYDI, MOHAMMAD KAMALINEZHAD, F. KHAMSEH, A. KHOUSHBATEN, ALI NOUROUZZADEH, F. ZIGHEYMAT, and HEDAYAT SAHRAEI, “STUDY OF THE EFFECTS OF INTRA-NUCLEUS ACCUMBENS SHELL INJECTIONS OF ALCOHLIC EXTRACT OF CROCUS SATIVUS ON THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 12, no. 2, pp. 121–128, 2008, [Online]. Available: https://sid.ir/paper/75014/en

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