RELAXATION OF PULMONARY VASCULAR SMOOTH MUSCLE BY CAMP-MEDIATED PATHWAYS

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KAVOLI HAGHIGHI M.

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Journal: Physiology and Pharmacology Year:2001 | Volume:4 | Issue:2 Page(s): 249-255

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Information Journal Paper

Title

RELAXATION OF PULMONARY VASCULAR SMOOTH MUSCLE BY CAMP-MEDIATED PATHWAYS

Author(s)

KAVOLI HAGHIGHI M. | Issue Writer Certificate

Keywords

ISOPRETERONOLQ4

HISTAMINEQ4

PULMONARY VESSELSQ4

VASODILATATIONQ4

CAMPQ4

Abstract

Adenosine 3', 5'-cyclic monophosphate (cAMP)-mediated pulmonary vascular smooth muscle relaxation is a principal mechanism of pulmonary vasomotor control. The purpose of this study was to compare the potency and efficacy of the following receptor-linked pathway for pulmonary vasorelaxation which are mediated by CAMP. The experiments were performed on the rat pulmonary artery rings using vasorelaxants including isoproterenol (ISO, ß2-adrenoceptoragonist), adenosine (AD, P1-purinoceptor agonist), adenosine 5' -diphosphate (ADP, P2-purinoceptor agonist), adenosine 5'- triphosphate (ATP, P2-purinoceptor agonist), and HISTAMINE (HIST, H2-histamine receptor agonist). All of these drugs induced dose-dependent relaxation in the rat artery rings precontracted with phenylephrine (100 nM) (PE, EC75). Dose-response curves for rat pulmonary artery rings were recorded isometrically with Grass FT03 transducers and displayed on a Grass model 7 polygraph. The results showed that ISO (100 pM to 10 µM), AD (30 µM to 100 µM), ADP and ATP (10 nM to 10 µM) and HIST (1 µM to 100 µM) induced dose-dependent relaxation in rat pulmonary artery rings. The maximum responses were for ISO, ADP and A1P (10 µM), AD (10 µM) and HIST (1 mM). In the preparations The maximum relaxant responses were for ISO (93.04±1.25%), ADP (78.39±2.68%), ATP (80.48±1.93%), AD (72.22±3%), and HIST (69.52±4.02%) respectively. The median effective concentrations (EC50) were 0.01 µM Physiology and Pharmacology Volume 4, Number 2 Fall & Winter 2000-2001 for ISO, 0.5 µM for ADP, 0.6 µM for ATP, 70 µM for AD, and 100 µM for HIST. These data revealed that although receptor-linked pathways and their activation of adenylate cycles and ensuing increased level of CAMP are responsible for relaxation in the artery rings, but there existed significant differences regarding potency and efficacy.

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APA: Copy

KAVOLI HAGHIGHI, M.. (2001). RELAXATION OF PULMONARY VASCULAR SMOOTH MUSCLE BY CAMP-MEDIATED PATHWAYS. PHYSIOLOGY AND PHARMACOLOGY, 4(2), 249-255. SID. https://sid.ir/paper/75026/en

Vancouver: Copy

KAVOLI HAGHIGHI M.. RELAXATION OF PULMONARY VASCULAR SMOOTH MUSCLE BY CAMP-MEDIATED PATHWAYS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2001;4(2):249-255. Available from: https://sid.ir/paper/75026/en

IEEE: Copy

M. KAVOLI HAGHIGHI, “RELAXATION OF PULMONARY VASCULAR SMOOTH MUSCLE BY CAMP-MEDIATED PATHWAYS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 4, no. 2, pp. 249–255, 2001, [Online]. Available: https://sid.ir/paper/75026/en

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