THE EFFECT OF FLUOXETINE ON CA1 AREA OF HIPPOCAMPUS ON SPATIAL LEARNING AND MEMORY USING MORRIS WATER MAZE IN MALE ADULT RATS

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NAGHDI N.; JALALVAND E.; HAERI ROUHANI SEYED ALI; MAJLESSI N.

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Journal: Physiology and Pharmacology Year:2001 | Volume:4 | Issue:2 Page(s): 219-228

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Title

THE EFFECT OF FLUOXETINE ON CA1 AREA OF HIPPOCAMPUS ON SPATIAL LEARNING AND MEMORY USING MORRIS WATER MAZE IN MALE ADULT RATS

Author(s)

NAGHDI N. | JALALVAND E. | HAERI ROUHANI SEYED ALI | MAJLESSI N. | Issue Writer Certificate

Keywords

FLUOXETINEQ4

HIPPOCAMPUSQ3

SPATIAL MEMORYQ3

RATQ3

MORRIS WATER MAZEQ4

Abstract

FLUOXETINE is an inhibitor of serotonin re-uptake with antidepressant properties. Since serotonin reuptake inhibitors have significant effects on processes undedying learning and memory, this study was conducted to investigate the effect of FLUOXETINE on spatial learning using MORRIS WATER MAZE (MWM). For this purpose, cannulae were inserted bilaterally into the CA1 region and each day 25 minutes before training, FLUOXETINE at doses of 0, 6, 12, 18 and 24 µg in 0.5 µl of distilled water was injected bilaterally through the cannulae. In spatial learning in MWM (continued for 3 days), the RATs must locate an invisible platform with a constant position during this period. On the fourth day, the platform was in a new position and visible to assess visuomotor coordination.The Results showed that FLUOXETINE caused an increase in latencies to find the invisible platform, traveled distance and heading angles compared to control group in a dose-dependent manner, but had no effect on visuomotor coordination.These finding suggested that spatial discrimination in MWM may be impaired by FLUOXETINE in a dose-dependent pattern.

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APA: Copy

NAGHDI, N., JALALVAND, E., HAERI ROUHANI, SEYED ALI, & MAJLESSI, N.. (2001). THE EFFECT OF FLUOXETINE ON CA1 AREA OF HIPPOCAMPUS ON SPATIAL LEARNING AND MEMORY USING MORRIS WATER MAZE IN MALE ADULT RATS. PHYSIOLOGY AND PHARMACOLOGY, 4(2), 219-228. SID. https://sid.ir/paper/75027/en

Vancouver: Copy

NAGHDI N., JALALVAND E., HAERI ROUHANI SEYED ALI, MAJLESSI N.. THE EFFECT OF FLUOXETINE ON CA1 AREA OF HIPPOCAMPUS ON SPATIAL LEARNING AND MEMORY USING MORRIS WATER MAZE IN MALE ADULT RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2001;4(2):219-228. Available from: https://sid.ir/paper/75027/en

IEEE: Copy

N. NAGHDI, E. JALALVAND, SEYED ALI HAERI ROUHANI, and N. MAJLESSI, “THE EFFECT OF FLUOXETINE ON CA1 AREA OF HIPPOCAMPUS ON SPATIAL LEARNING AND MEMORY USING MORRIS WATER MAZE IN MALE ADULT RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 4, no. 2, pp. 219–228, 2001, [Online]. Available: https://sid.ir/paper/75027/en

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