Inhalant Self-Administration of Methamphetamine: The Most Similar Model to Human Methamphetamine Addiction

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RAFAIEE RAHELEH; AHMADIANKIA NAGHMEH; MOUSAVI SEYED ABBAS; Rezaeian Leila; Niroumand Sarvandani Mohammad; Shekari Ahmad; FOROUZESH MEHDI; Valipour Roohollah; KALALIAN MOGHADAM HAMID

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Journal: Iranian Journal of Psychiatry and Behavioral Sciences Year:2019 | Volume:13 | Issue:3 Page(s): 0-0

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Title

Inhalant Self-Administration of Methamphetamine: The Most Similar Model to Human Methamphetamine Addiction

Author(s)

Keywords

Drug Abuse

Animal Model

Self-Administration

Inhalation

Methamphetamine

Abstract

Background: Methamphetamine (meth) is recognized as a highly addictive psychostimulant. Currently, there are no available treatments for meth abuse, and no Animal Model of meth Self-Administration has been proposed to represent human meth selfadministration. Objectives: We aimed to develop a model to study meth Self-Administration through Inhalation in rats. Methods: Rats were placed in an inhaler apparatus (designed specifically for this purpose) for 15 min per day over two weeks. There were two levers in the cage. Pressing the passive lever had no outcomes. Whereas, for each active lever pressing, an infusion pump delivered 50 L of meth or distilled water within two seconds. Meth was evaporated on a hot plate adjacent to the rat cage. After loading the drug over the hot plate, the blower fan was run, and the vaporized drug was blown by the fan into the rat cage. Then, meth-induced conditioned place preference and locomotor activity were assessed following 14 days of meth Inhalation. The serum concentration of meth was also determined by gas chromatography-mass spectrometry. Results: In this model, the Self-Administration of meth through Inhalation significantly increased locomotor activity, conditioned place preference, and plasma level of meth. Conclusions: We can conclude that the Self-Administration of meth through Inhalation is a novel and effective route of selfadministration. Ournewprotocol presents a promising tool for examining drug-seeking/taking behaviorsandneural consequences in a noninvasive approach to reduce the stress of surgery and injection in laboratory animals and increase the validity of animal experiments.

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APA: Copy

RAFAIEE, RAHELEH, AHMADIANKIA, NAGHMEH, MOUSAVI, SEYED ABBAS, Rezaeian, Leila, Niroumand Sarvandani, Mohammad, Shekari, Ahmad, FOROUZESH, MEHDI, Valipour, Roohollah, & KALALIAN MOGHADAM, HAMID. (2019). Inhalant Self-Administration of Methamphetamine: The Most Similar Model to Human Methamphetamine Addiction. IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS), 13(3), 0-0. SID. https://sid.ir/paper/750350/en

Vancouver: Copy

RAFAIEE RAHELEH, AHMADIANKIA NAGHMEH, MOUSAVI SEYED ABBAS, Rezaeian Leila, Niroumand Sarvandani Mohammad, Shekari Ahmad, FOROUZESH MEHDI, Valipour Roohollah, KALALIAN MOGHADAM HAMID. Inhalant Self-Administration of Methamphetamine: The Most Similar Model to Human Methamphetamine Addiction. IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS)[Internet]. 2019;13(3):0-0. Available from: https://sid.ir/paper/750350/en

IEEE: Copy

RAHELEH RAFAIEE, NAGHMEH AHMADIANKIA, SEYED ABBAS MOUSAVI, Leila Rezaeian, Mohammad Niroumand Sarvandani, Ahmad Shekari, MEHDI FOROUZESH, Roohollah Valipour, and HAMID KALALIAN MOGHADAM, “Inhalant Self-Administration of Methamphetamine: The Most Similar Model to Human Methamphetamine Addiction,” IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS), vol. 13, no. 3, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/750350/en

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