EFFECT OF PRE-TREATMENT WITH OXYTOCIN ON CARDIAC ENZYMES IN REGIONAL ISCHEMIA-REPERFUSION INJURY INDUCED IN THE RAT HEART

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ALIZADEH ALI MOHAMMAD; FAGHIHI MAHDIEH; KHORI VAHID; MOHSENIKIA MARYAM

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Journal: Physiology and Pharmacology Year:2012 | Volume:15 | Issue:4 Page(s): 572-582

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Title

EFFECT OF PRE-TREATMENT WITH OXYTOCIN ON CARDIAC ENZYMES IN REGIONAL ISCHEMIA-REPERFUSION INJURY INDUCED IN THE RAT HEART

Author(s)

ALIZADEH ALI MOHAMMAD | FAGHIHI MAHDIEH | KHORI VAHID | MOHSENIKIA MARYAM | Issue Writer Certificate

Keywords

ISCHEMIA-REPERFUSIONQ3

OXYTOCINQ3

5-HYDROXYDECANOICQ2

ATRACTYLOSIDEQ2

CHELYTRAINEQ2

N-ACETYLCYSTEINEQ2

Abstract

Introduction: Cardiac preconditioning represents the most potent and consistently reproducible method of rescuing heart tissue from undergoing irreversible ischemic damage. The aim of the present study was to evaluate OXYTOCIN (OT) induced cardioprotection and its signaling pathways on lactate dehydrogenase (LDH) and creatine kinase-MB isoenzyme (CK-MB) in the anesthetized rats.Methods: Eighty-four rats were divided into fourteen groups. Animal’s hearts were subjected to 25 min ischemia and 2 h reperfusion (I/R). OXYTOCIN (0.03 mg/kg) was used 25 min prior to ischemia. Atosiban, an OT receptor antagonist (1.5 mg/kg), 5-HYDROXYDECANOIC acid, an inhibitor of mitochondrial ATP-dependent potassium channel (10 mg/kg), ATRACTYLOSIDE, an opener of mitochondrial permeability transition pores (5 mg/kg), CHELYTRAINE, a protein kinase C inhibitor (5 mg/kg) and N-ACETYLCYSTEINE, a reactive oxygen species scavenger (200 mg/kg) were used 10 min prior to OT administration. Then, LDH and CK-MB levels in plasma were measured.Results: OT administration significantly decreased CK-MB and LDH levels compared to I/R group. Administration of atosiban, 5-HYDROXYDECANOIC, ATRACTYLOSIDE, CHELYTRAINE and N-ACETYLCYSTEINE abolished the cardiac preconditioning effect of OT.Conclusion: The present study demonstrates that OXYTOCIN cardioprotective effects are complex and its signaling pathways may mediate through mKATP channels, mPTP, PKC activation and increase ROS.

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APA: Copy

ALIZADEH, ALI MOHAMMAD, FAGHIHI, MAHDIEH, KHORI, VAHID, & MOHSENIKIA, MARYAM. (2012). EFFECT OF PRE-TREATMENT WITH OXYTOCIN ON CARDIAC ENZYMES IN REGIONAL ISCHEMIA-REPERFUSION INJURY INDUCED IN THE RAT HEART. PHYSIOLOGY AND PHARMACOLOGY, 15(4), 572-582. SID. https://sid.ir/paper/75042/en

Vancouver: Copy

ALIZADEH ALI MOHAMMAD, FAGHIHI MAHDIEH, KHORI VAHID, MOHSENIKIA MARYAM. EFFECT OF PRE-TREATMENT WITH OXYTOCIN ON CARDIAC ENZYMES IN REGIONAL ISCHEMIA-REPERFUSION INJURY INDUCED IN THE RAT HEART. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2012;15(4):572-582. Available from: https://sid.ir/paper/75042/en

IEEE: Copy

ALI MOHAMMAD ALIZADEH, MAHDIEH FAGHIHI, VAHID KHORI, and MARYAM MOHSENIKIA, “EFFECT OF PRE-TREATMENT WITH OXYTOCIN ON CARDIAC ENZYMES IN REGIONAL ISCHEMIA-REPERFUSION INJURY INDUCED IN THE RAT HEART,” PHYSIOLOGY AND PHARMACOLOGY, vol. 15, no. 4, pp. 572–582, 2012, [Online]. Available: https://sid.ir/paper/75042/en

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