A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis

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SADEGHI ALIREZA; Nejati Maliheh; MOGHADDAS AZADEH

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2019 | Volume:44 | Issue:4 Page(s): 342-346

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Title

A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis

Author(s)

SADEGHI ALIREZA | Nejati Maliheh | MOGHADDAS AZADEH | Issue Writer Certificate

Keywords

Liver failure

Multiple myeloma

Amyloidosis

Hyperbilirubinemia

Abstract

The clinically reported case of liver involvement with Multiple myeloma (MM) is rare. Amyloidosis, defined as a tissue deposition of clonal light-chain fibrils, has been reported in 10-15% of the MM patients. We described a rare MM patient with the primal presentation of fulminant hepatic failure and biliary system involvement due to Amyloidosis. Our patient had the primal symptoms of Hyperbilirubinemia, ascites, hepatosplenomegaly, and anemia. Chemotherapy with a standard regimen containing bortezomib, thalidomide, and dexamethasone was implemented and led to a dramatic response. Liver involvement due to light chain Amyloidosis can be the first drastic presentation of MM. It is important to consider infiltrative disorders, like MM and Amyloidosis, when patients present non-specific symptoms and impaired liver function tests. Proper and timely diagnosis can directly affect the prognosis of patients. The optimal approach in the standard management of similar cases is still a matter of debate.

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APA: Copy

SADEGHI, ALIREZA, Nejati, Maliheh, & MOGHADDAS, AZADEH. (2019). A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 44(4), 342-346. SID. https://sid.ir/paper/750526/en

Vancouver: Copy

SADEGHI ALIREZA, Nejati Maliheh, MOGHADDAS AZADEH. A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2019;44(4):342-346. Available from: https://sid.ir/paper/750526/en

IEEE: Copy

ALIREZA SADEGHI, Maliheh Nejati, and AZADEH MOGHADDAS, “A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 44, no. 4, pp. 342–346, 2019, [Online]. Available: https://sid.ir/paper/750526/en

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