Preventive Effects of Duloxetine Against Methamphetamine Induced Neurodegeneration and Motor Activity Disorder in Rat: Possible Role of CREB/BDNF Signaling Pathway

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MOHAMMADI NILOOFAR; Taheri Parastoo; Shahmoradi Elaheh; MOTAGHINEJAD MAJID; GHOLAMI MINA; MOTEVALIAN MANIJEH

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Journal: International Journal of Preventive Medicine Year:2019 | Volume:10 | Issue:- Page(s): 0-0

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Title

Preventive Effects of Duloxetine Against Methamphetamine Induced Neurodegeneration and Motor Activity Disorder in Rat: Possible Role of CREB/BDNF Signaling Pathway

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Keywords

Duloxetine

methamphetamine

motor activity

neurodegeneration

P‑CREB/BDNF pathway

Abstract

Background: The neuroprotective effects of Duloxetine and neurodegenerative effects of methamphetamine have been shown in previous studies, but their exact mechanism remain unclear. In the current study it involved molecular mechanisms of neuroprotective effects of Duloxetine against methamphetamine induced neurodegeneration were clarified. Methods: About 40 adult male rats randomly were divided to 5 groups. Group 1 and 2, as control and methamphetamine treated, received normal saline and methamphetamine (10 mg/kg) respectively. Groups 3, 4 and 5 concurrently treated with methamphetamine and Duloxetine at doses of 10, 20 and 30 mg/kg respectively. All treatments were undertaken for 21 days. On day 22 Open Field Test (OFT) were used to examine the level of motor activity disturbance and anxiety in animals. After that hippocampus was isolated from each rat and oxidative, antioxidant, inflammatory factors and also level or expression of total and phosphorylated forms of CREB and P‑ CREB and BDNF proteins were measured. Results: Duloxetine in all mentioned doses could inhibit the effects of methamphetamine induced motor activity disturbance in MWM. Chronic abuse of methamphetamine could increase malondialdehyde (MDA), tumor necrosis factor‑ Alpha (TNF‑ α ) and interleukine‑ 1beta (IL‑ 1β ) while caused decreases in superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) activities and decreased CREB (both forms) and BDNF proteins, while Duloxetine could prevent these malicious effects of methamphetamine. Conclusions: We conclude that P‑ CREB/ BDNF signaling pathways might have critical role in Duloxetine neuroprotective effects against methamphetamine induced neurodegeneration.

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APA: Copy

MOHAMMADI, NILOOFAR, Taheri, Parastoo, Shahmoradi, Elaheh, MOTAGHINEJAD, MAJID, GHOLAMI, MINA, & MOTEVALIAN, MANIJEH. (2019). Preventive Effects of Duloxetine Against Methamphetamine Induced Neurodegeneration and Motor Activity Disorder in Rat: Possible Role of CREB/BDNF Signaling Pathway. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 10(-), 0-0. SID. https://sid.ir/paper/750903/en

Vancouver: Copy

MOHAMMADI NILOOFAR, Taheri Parastoo, Shahmoradi Elaheh, MOTAGHINEJAD MAJID, GHOLAMI MINA, MOTEVALIAN MANIJEH. Preventive Effects of Duloxetine Against Methamphetamine Induced Neurodegeneration and Motor Activity Disorder in Rat: Possible Role of CREB/BDNF Signaling Pathway. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2019;10(-):0-0. Available from: https://sid.ir/paper/750903/en

IEEE: Copy

NILOOFAR MOHAMMADI, Parastoo Taheri, Elaheh Shahmoradi, MAJID MOTAGHINEJAD, MINA GHOLAMI, and MANIJEH MOTEVALIAN, “Preventive Effects of Duloxetine Against Methamphetamine Induced Neurodegeneration and Motor Activity Disorder in Rat: Possible Role of CREB/BDNF Signaling Pathway,” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 10, no. -, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/750903/en

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