The Nitrate-Nitrite-Nitric Oxide Pathway: Findings from 20 Years of the Tehran Lipid and Glucose Study

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BAHADORAN ZAHRA; MIRMIRAN PARVIN; JEDDI SAJAD; MOMENAN AMIR ABBAS; AZIZI FEREIDOUN; GHASEMI ASGHAR

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Journal: International Journal of Endocrinology and Metabolism Year:2018 | Volume:16 | Issue:suppl 4 Page(s): 0-0

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Title

The Nitrate-Nitrite-Nitric Oxide Pathway: Findings from 20 Years of the Tehran Lipid and Glucose Study

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Keywords

Nitric Oxide

Nitrate

Nitrite

Diabetes

Obesity

Metabolic Syndrome

Cardiovascular Disease

Abstract

Context: We describe here the contributions of the Tehran lipid and glucose study (TLGS) to understanding different aspects of the Nitrate (NO3)-Nitrite (NO2)-Nitric Oxide (NO) pathway in health and disease. Evidence Acquisition: All English-language documents from the TLGS, focused on NO pathway were searched using the PubMed, Scopus, and Embase databases. Results: Reference values of serum concentrations of NO metabolites (Nitrate+Nitrite or NOx) were 11. 5-76. 4, 10. 1-65. 6, and 10. 3-66. 8 mol/L inmen, women, andthe total population, respectively. CirculatingNOxwasaffected by age, smokinghabits, menopause status, thyroid hormones, and various pathologic conditions. Elevated serum NOx was related to increased incidence of Metabolic Syndrome (odds ratio (OR) = 1. 75, 95% confidence interval (CI) = 1. 19-2. 59), hypertriglyceridemic-waist phenotype (OR = 1. 39, 95% CI = 1. 05-1. 93), chronic kidney disease (OR = 1. 86, 95% CI = 1. 10-3. 14) in women, and Cardiovascular Disease (hazard ratio (HR) = 1. 35, 95% CI = 1. 01-1. 80] in the total population. In participants with low vitamin C intake, higher intakes of NO2 ( 8. 77 mg/d) were accompanied with increased risk of Diabetes (HR = 2. 43, 95% CI = 1. 45-4. 05). A decreased risk of hypertension (OR = 0. 58, 95% CI = 0. 33-0. 98) and chronic kidney disease (OR = 0. 50, 95% CI = 0. 24-0. 89) was observed in response to higher intakes of NO2. Conclusions: Circulating NOx is associated with and could predict the risk of metabolic disorders in a general population. Moreover, dietary NO3/NO2 exposure from usual diets seems to contribute to development of noncommunicable diseases.

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APA: Copy

BAHADORAN, ZAHRA, MIRMIRAN, PARVIN, JEDDI, SAJAD, MOMENAN, AMIR ABBAS, AZIZI, FEREIDOUN, & GHASEMI, ASGHAR. (2018). The Nitrate-Nitrite-Nitric Oxide Pathway: Findings from 20 Years of the Tehran Lipid and Glucose Study. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 16(4 (Suppl.)), 0-0. SID. https://sid.ir/paper/751008/en

Vancouver: Copy

BAHADORAN ZAHRA, MIRMIRAN PARVIN, JEDDI SAJAD, MOMENAN AMIR ABBAS, AZIZI FEREIDOUN, GHASEMI ASGHAR. The Nitrate-Nitrite-Nitric Oxide Pathway: Findings from 20 Years of the Tehran Lipid and Glucose Study. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2018;16(4 (Suppl.)):0-0. Available from: https://sid.ir/paper/751008/en

IEEE: Copy

ZAHRA BAHADORAN, PARVIN MIRMIRAN, SAJAD JEDDI, AMIR ABBAS MOMENAN, FEREIDOUN AZIZI, and ASGHAR GHASEMI, “The Nitrate-Nitrite-Nitric Oxide Pathway: Findings from 20 Years of the Tehran Lipid and Glucose Study,” INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 16, no. 4 (Suppl.), pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/751008/en

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