DIFFERENT FORMS OF SYNAPTIC PLASTICITY ARE INDUCED AS A RESULT OF MORPHINE DEPENDENCE IN THE RAT HIPPOCAMPUS

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SALMANZADEH F.; FATH ELAHI Y.; SEMNANIAN S.; SHAFIZADEH MAHSHID

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Title

DIFFERENT FORMS OF SYNAPTIC PLASTICITY ARE INDUCED AS A RESULT OF MORPHINE DEPENDENCE IN THE RAT HIPPOCAMPUS

Author(s)

SALMANZADEH F. | FATH ELAHI Y. | SEMNANIAN S. | SHAFIZADEH MAHSHID | Issue Writer Certificate

Keywords

SYNAPTIC PLASTICITYQ4

BRAIN SLICESQ4

ADDICTIONQ3

MORPHINEQ3

HIPPOCAMPUSQ3

Abstract

Since long-term potentiation (LTP) is potentially the cellular basis of learning and memory, we studied the probable alterations of this phenomenon in hippocampal slices of MORPHINE-dependent rats. Field EPSP (fEPSP) and orthodromic poulation spikes (OPS) were recorded from stratums radiatum and pyramidale of CA1 area following stimulation of Schaffer collaterals, in control and dependent slices respectively. To induce LTP, primed bursts (PBs) tetanic stimulation was used at frequencies of 100 and 200 Hz. The results showed that tetanus at a frequency of 100 Hz induced an enhanced OPS LTP in dependent slices as compared to control ones, while the magnitude of fEPSP LTP did not change in those slices. In response to 200 Hz tetanus, OPS LTP was induced in both control and dependent slices which was similar in magnitude, but different in time course. These findings suggest that OPS LTP can be proposed as a suitable electrophysiological tool for detection of long-term effects of chronic MORPHINE exposure. In addition, MORPHINE dependence may result in EPSP-Spike potentiation with a tendency toward VDCCs mechanisms in hippocampal CA1 synapses. Such probable changes in SYNAPTIC PLASTICITY may underlie cellular and molecular bases of cognitive deficits as a result of opiate ADDICTION.

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APA: Copy

SALMANZADEH, F., FATH ELAHI, Y., SEMNANIAN, S., & SHAFIZADEH, MAHSHID. (2003). DIFFERENT FORMS OF SYNAPTIC PLASTICITY ARE INDUCED AS A RESULT OF MORPHINE DEPENDENCE IN THE RAT HIPPOCAMPUS. PHYSIOLOGY AND PHARMACOLOGY, 6(2), 133-142. SID. https://sid.ir/paper/75101/en

Vancouver: Copy

SALMANZADEH F., FATH ELAHI Y., SEMNANIAN S., SHAFIZADEH MAHSHID. DIFFERENT FORMS OF SYNAPTIC PLASTICITY ARE INDUCED AS A RESULT OF MORPHINE DEPENDENCE IN THE RAT HIPPOCAMPUS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2003;6(2):133-142. Available from: https://sid.ir/paper/75101/en

IEEE: Copy

F. SALMANZADEH, Y. FATH ELAHI, S. SEMNANIAN, and MAHSHID SHAFIZADEH, “DIFFERENT FORMS OF SYNAPTIC PLASTICITY ARE INDUCED AS A RESULT OF MORPHINE DEPENDENCE IN THE RAT HIPPOCAMPUS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 6, no. 2, pp. 133–142, 2003, [Online]. Available: https://sid.ir/paper/75101/en

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