IN VITRO EFFECTS OF PROPRANOLOL AND YOHIMBINE ON PHAGOCYTIC ACTIVITY OF MACROPHAGES IN RAINBOW TROUT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

VAHDATI A.; FATEMI M.; KHERADMANDNIA M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2003 | Volume:6 | Issue:2 Page(s): 227-234

Download Full-Text

Persian Verion

View:

1,118

Download:

Cites:

Information Journal Paper

Title

IN VITRO EFFECTS OF PROPRANOLOL AND YOHIMBINE ON PHAGOCYTIC ACTIVITY OF MACROPHAGES IN RAINBOW TROUT

Author(s)

VAHDATI A. | FATEMI M. | KHERADMANDNIA M. | Issue Writer Certificate

Keywords

PROPRANOLOLQ3

YOHIMBINEQ4

CATECHOLAMINEQ4

PHAGOCYTOSISQ4

RAINBOW TROUTQ4

Abstract

PROPRANOLOL and YOHIMBINE are two antagonists of adrenergic receptors (Beta and Alfa2 respectively), blocking the actions of CATECHOLAMINEs. Besides a number of effects on metabolic processes, CATECHOLAMINEs influence the body immune system (i.e. the activity of macro phages). As in other vertebrates, macrophages of the fish play a critical role in getting rid of the pathogenic particles. However, the depressive effect of increased levels of CATECHOLAMINEs on phagocytic activity of macrophages has not been investigated yet. Therefore, for studying this effect on phagocytic activity, suspensions from pronephros of RAINBOW TROUT were prepared. Increasing doses of PROPRANOLOL or YOHIMBINE (0, 0.5, 1, 2.5, 5 and 10 mg/ml) were added to the suspensions. The suspensions were then incubated with adrenaline (4 µg/ml). The results indicated that a significant decrease (P<0.01) in PHAGOCYTOSIS existed in suspensions incubated with adrenaline alone. Furthermore, a significant increase (P<0.01) in PHAGOCYTOSIS was observed in suspensions incubated with either of the antagonists plus adrenaline. In addition, the effect of YOHIMBINE was greater than the effect of PROPRANOLOL (P<0.01). These results suggest that both PROPRANOLOL and YOHIMBINE could inhibit the depressant effect of adrenaline on the phagocytic activity of macrophages in RAINBOW TROUT.

Cites

No record.

References

No record.

Cite

APA: Copy

VAHDATI, A., FATEMI, M., & KHERADMANDNIA, M.. (2003). IN VITRO EFFECTS OF PROPRANOLOL AND YOHIMBINE ON PHAGOCYTIC ACTIVITY OF MACROPHAGES IN RAINBOW TROUT. PHYSIOLOGY AND PHARMACOLOGY, 6(2), 227-234. SID. https://sid.ir/paper/75102/en

Vancouver: Copy

VAHDATI A., FATEMI M., KHERADMANDNIA M.. IN VITRO EFFECTS OF PROPRANOLOL AND YOHIMBINE ON PHAGOCYTIC ACTIVITY OF MACROPHAGES IN RAINBOW TROUT. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2003;6(2):227-234. Available from: https://sid.ir/paper/75102/en

IEEE: Copy

A. VAHDATI, M. FATEMI, and M. KHERADMANDNIA, “IN VITRO EFFECTS OF PROPRANOLOL AND YOHIMBINE ON PHAGOCYTIC ACTIVITY OF MACROPHAGES IN RAINBOW TROUT,” PHYSIOLOGY AND PHARMACOLOGY, vol. 6, no. 2, pp. 227–234, 2003, [Online]. Available: https://sid.ir/paper/75102/en

Related Journal Papers