THE EFFECT OF LOCAL AND CHRONIC ADMINISTRATION OF MORPHINE ON LIDOCAINE-INDUCED ANALGESIA IN RATS

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MOEINI ZANJANI T.; SABET KASAEI M.

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Journal: Physiology and Pharmacology Year:2003 | Volume:6 | Issue:2 Page(s): 221-226

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Title

THE EFFECT OF LOCAL AND CHRONIC ADMINISTRATION OF MORPHINE ON LIDOCAINE-INDUCED ANALGESIA IN RATS

Author(s)

MOEINI ZANJANI T. | SABET KASAEI M. | Issue Writer Certificate

Keywords

MORPHINEQ3

ADDICTIONQ3

LIDOCAINEQ3

ANALGESIAQ4

RATQ3

Abstract

Recent evidences have shown that MORPHINE has peripheral analgesic effects. In this study, the effect of local and chronic administration of MORPHINE on LIDOCAINE-induced local sensory block was investigated using a RAT model of peripheral ANALGESIA. The experiments were performed on adult male Sprague-Dawley RATs (180-250 g; n=6) in 5 groups: 1) saline + saline (control), 2) MORPHINE + saline, 3) LIDOCAINE-saline, 4) MORPHINE + LIDOCAINE, 5) LIDOCAINE+ saline in addicted RATs (animals received cmomc doses of MORPHINE in their drinking water for 21 days). In all groups, pain tolerance was assessed using hot plate test (55±0.5°c) on paw licking behavior before and 16 min after drug administration. The anti-nociceptive effect of intraplantar MORPHINE (200, 400, and 800 µg), LIDOCAINE (0.25, 0.5, 1, and 2%), Co administration of non-analgesic doses of MORPHINE (200 µg) and LIDOCAINE (1 %) in non-addicted RATs and LIDOCAINE (0.25, 0.5, 1, and 2%) in addicted RATs were evaluated. The results showed that intraplantar injection of LIDOCAINE produced analgesic effect in both addicted and non-addicted RATs compared to controls. Furthermore, MORPHINE produced local anti-nociceptive effect. Co administration of non-analgesic doses of MORPHINE and LIDOCAINE produced a potentiated analgesic effect. Meanwhile, the analgesic effect of LIDOCAINE was potentiated in addicted RATs. These data support that local and chronic use of MORPHINE can potentiate local analgesic effect of LIDOCAINE.

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APA: Copy

MOEINI ZANJANI, T., & SABET KASAEI, M.. (2003). THE EFFECT OF LOCAL AND CHRONIC ADMINISTRATION OF MORPHINE ON LIDOCAINE-INDUCED ANALGESIA IN RATS. PHYSIOLOGY AND PHARMACOLOGY, 6(2), 221-226. SID. https://sid.ir/paper/75104/en

Vancouver: Copy

MOEINI ZANJANI T., SABET KASAEI M.. THE EFFECT OF LOCAL AND CHRONIC ADMINISTRATION OF MORPHINE ON LIDOCAINE-INDUCED ANALGESIA IN RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2003;6(2):221-226. Available from: https://sid.ir/paper/75104/en

IEEE: Copy

T. MOEINI ZANJANI, and M. SABET KASAEI, “THE EFFECT OF LOCAL AND CHRONIC ADMINISTRATION OF MORPHINE ON LIDOCAINE-INDUCED ANALGESIA IN RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 6, no. 2, pp. 221–226, 2003, [Online]. Available: https://sid.ir/paper/75104/en

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