THE EFFECT OF GLUCOSE ON MK-801-INDUCED AMNESIA IN RAT

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MOAZEDI A.A.; EBRAHIMI S.; CHINIPARDAZ R.

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Journal: Physiology and Pharmacology Year:2003 | Volume:6 | Issue:2 Page(s): 183-190

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Title

THE EFFECT OF GLUCOSE ON MK-801-INDUCED AMNESIA IN RAT

Author(s)

MOAZEDI A.A. | EBRAHIMI S. | CHINIPARDAZ R. | Issue Writer Certificate

Keywords

SPATIAL LEARNINGQ4

COMPUTERIZED Y-MAZEQ4

NMDAQ4

GLUCOSEQ3

RATQ3

Abstract

Extensive evidence strongly suggest that modest increases in circulating GLUCOSE modulate learning and memory processes, but researches on elucidating the physiological basis of this action are still continuing. In the present study, we investigated the effect of GLUCOSE on amnesia induced by the non-competitive NMDA antagonist, Mk-80l in RATs. AY-maze apparatus, controlled by computer, was used for active avoidance conditioning in male NMRI RATs. The first group of RATs received 1000 mg/kg of GLUCOSE immediately following the training, the second groups received 0.06 mg/kg of Mk-80 I 30 min before training and the third group received Mk-801 (0.06 mg/kg) before training and GLUCOSE (1000 mg/kg) after training, while control groups received only saline at the same volume. The results showed that GLUCOSE not only does improve the dementia induced by Mk-BOI (P<0.01), but also it increases the learning process (P<0.05). It can be concluded that GLUCOSE might have played its most effects through mechanisms other than NMDA receptors.

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References

مقایسه یادگیری فضایی در موش های صحرایی نر و ماده با استفاده از دستگاه Y-maze کامپیوتری

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APA: Copy

MOAZEDI, A.A., EBRAHIMI, S., & CHINIPARDAZ, R.. (2003). THE EFFECT OF GLUCOSE ON MK-801-INDUCED AMNESIA IN RAT. PHYSIOLOGY AND PHARMACOLOGY, 6(2), 183-190. SID. https://sid.ir/paper/75105/en

Vancouver: Copy

MOAZEDI A.A., EBRAHIMI S., CHINIPARDAZ R.. THE EFFECT OF GLUCOSE ON MK-801-INDUCED AMNESIA IN RAT. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2003;6(2):183-190. Available from: https://sid.ir/paper/75105/en

IEEE: Copy

A.A. MOAZEDI, S. EBRAHIMI, and R. CHINIPARDAZ, “THE EFFECT OF GLUCOSE ON MK-801-INDUCED AMNESIA IN RAT,” PHYSIOLOGY AND PHARMACOLOGY, vol. 6, no. 2, pp. 183–190, 2003, [Online]. Available: https://sid.ir/paper/75105/en

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