INFLUENCE OF MEPERIDINE ON ACTION POTENTIAL AND UNDERLYING IONIC CURRENTS OF FL NEURON IN HELIX ASPERSA

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JELVEH MOGHADAM H.A.; JANAHMADI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Physiology and Pharmacology Year:2003 | Volume:6 | Issue:2 Page(s): 153-162

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Title

INFLUENCE OF MEPERIDINE ON ACTION POTENTIAL AND UNDERLYING IONIC CURRENTS OF FL NEURON IN HELIX ASPERSA

Author(s)

JELVEH MOGHADAM H.A. | JANAHMADI M. | Issue Writer Certificate

Keywords

MEPERIDINEQ3

IONIC CURRENTSQ4

EXCITABILITYQ3

INTRACELLULAR RECORDINGQ3

Abstract

Local anesthetic agents are well known to interrupt impulse conduction in peripheral nerve axons when applied locally in high concentration. The phenylpiperidine opioid, meperidirie, in addition to its systemic opioid effects, also shows local anesthetic-like action, when applied directly to peripheral nerves. The opioid MEPERIDINE induces anesthesia and blocks action potentials. The local anesthetic effects of MEPERIDINE has been demonstrated in both clinical and laboratory studies. Clinically, it can produce segmental sensory anesthesia. However, most of the previous studies on the effects of MEPERIDINE on nerve conduction have all made use of peripheral nerve preparations and yielded conflicting results. In the present study, we have characterized the effects of MEPERIDINE on IONIC CURRENTS underlying neuronal EXCITABILITY, using current-clamp and two-electrode voltage-clamp techniques. The results showed that FI neurons of the garden snail, Helix aspersa, respond to MEPERIDINE by significantly decreasing the peak amplitude and significantly increasing the duration of action 11 potentials. Voltage-clamp experiments revealed that MEPERIDINE depressed the macroscopic inward and increased outward K + currents. In conclusion, these findings indicate that MEPERIDINE decreases the EXCITABILITY in Helix aspersa nervous system by decreasing inward IONIC CURRENTS and increasing outward currents underlying the action potential.

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APA: Copy

JELVEH MOGHADAM, H.A., & JANAHMADI, M.. (2003). INFLUENCE OF MEPERIDINE ON ACTION POTENTIAL AND UNDERLYING IONIC CURRENTS OF FL NEURON IN HELIX ASPERSA. PHYSIOLOGY AND PHARMACOLOGY, 6(2), 153-162. SID. https://sid.ir/paper/75106/en

Vancouver: Copy

JELVEH MOGHADAM H.A., JANAHMADI M.. INFLUENCE OF MEPERIDINE ON ACTION POTENTIAL AND UNDERLYING IONIC CURRENTS OF FL NEURON IN HELIX ASPERSA. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2003;6(2):153-162. Available from: https://sid.ir/paper/75106/en

IEEE: Copy

H.A. JELVEH MOGHADAM, and M. JANAHMADI, “INFLUENCE OF MEPERIDINE ON ACTION POTENTIAL AND UNDERLYING IONIC CURRENTS OF FL NEURON IN HELIX ASPERSA,” PHYSIOLOGY AND PHARMACOLOGY, vol. 6, no. 2, pp. 153–162, 2003, [Online]. Available: https://sid.ir/paper/75106/en

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