Laminin Receptor 1: Can It Have a Role in Molecular Classification and Targeted Therapy of Endometrial Cancer?

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KURDOGLU MERTIHAN

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Journal Paper

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Journal: International Journal of Women's Health and Reproduction Sciences Year:2019 | Volume:7 | Issue:3 Page(s): -

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Title

Laminin Receptor 1: Can It Have a Role in Molecular Classification and Targeted Therapy of Endometrial Cancer?

Author(s)

KURDOGLU MERTIHAN | Issue Writer Certificate

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Abstract

Endometrial carcinomas which account for more than 90% of uterine cancer cases are the most common gynecologic malignancies of the female reproductive organs. Thanks to the recent molecular studies, genomic alterations leading to the pathogenesis of these types of cancers have been revealed extensively. Nowadays, conventional pathologic diagnoses of them do not seem to be able to sufficiently guide the optimal clinical managements and therefore, efforts to develop a new classification system based on their molecular-morphologic features is highly encouraged (1). Publication of the Cancer Genome Atlas (TCGA) report on a genomic analysis of 373 endometrial carcinomas (2) forced the efforts to incorporate molecular testing into routine histologic evaluation (3). Although DNA polymerase epsilon, catalytic subunit (POLE), mismatch repair (MMR), and human epidermal growth factor receptor 2 (HER2) are highly evaluated molecular tests due to potential efficacy of immune checkpoint inhibitors and other targeted therapies, the data is not sufficient to attain a clear consensus on which tests to perform...

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APA: Copy

KURDOGLU, MERTIHAN. (2019). Laminin Receptor 1: Can It Have a Role in Molecular Classification and Targeted Therapy of Endometrial Cancer?. INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES, 7(3), -. SID. https://sid.ir/paper/751416/en

Vancouver: Copy

KURDOGLU MERTIHAN. Laminin Receptor 1: Can It Have a Role in Molecular Classification and Targeted Therapy of Endometrial Cancer?. INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES[Internet]. 2019;7(3):-. Available from: https://sid.ir/paper/751416/en

IEEE: Copy

MERTIHAN KURDOGLU, “Laminin Receptor 1: Can It Have a Role in Molecular Classification and Targeted Therapy of Endometrial Cancer?,” INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES, vol. 7, no. 3, pp. –, 2019, [Online]. Available: https://sid.ir/paper/751416/en

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