EFFECT OF COMBINED ADMINISTRATION OF ZINC CHLORIDE AND ALUMINUM CHLORIDE ON MEMORY AND MOTOR ACTIVITY OF YOUNG RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHOTB ALDIN Z.; MOAZEDI A.A.; PARHAM GH.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2007 | Volume:11 | Issue:2 Page(s): 146-152

Download Full-Text

Persian Verion

View:

1,331

Download:

Cites:

Information Journal Paper

Title

EFFECT OF COMBINED ADMINISTRATION OF ZINC CHLORIDE AND ALUMINUM CHLORIDE ON MEMORY AND MOTOR ACTIVITY OF YOUNG RATS

Author(s)

GHOTB ALDIN Z. | MOAZEDI A.A. | PARHAM GH.A. | Issue Writer Certificate

Keywords

ZINC CHLORIDEQ3

ALUMINUM CHLORIDEQ2

SHUTTLE BOXQ3

ROTARODQ3

RATQ3

Abstract

Introduction: Aluminum is known as a neurotoxic element which causes neurodegeneration, learning deduction and movement disorders. Aluminum ions in the brain cause serious problems such as Alzheimer, Parkinson and other degenerative diseases. On the other hand, Zinc is a dietary element essential for several biological processes, modulates neurotransmission in brain regions and associates with cognition. Apoptosis plays a role in many neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Imbalances of this metal, either excess or deficiency, can result in neuronal apoptosis. Here we have studied the effect of their co-administration on memory and motor activity.Methods: ZINC CHLORIDE (30 mg/kg/day) and ALUMINUM CHLORIDE (600 mg/kg/day) were co-administered in drinking water of male RATs for two weeks. Two criteria were assessed in behavioral tests: latency to enter and time spent in dark. Motor resistance and coordination were evaluated in movement studies.Results: Experiments showed that following 2 weeks co-administration of ZnCI2 (30 mg/kg/day) and AICI3 (600 mg/kg/day), passive avoidance memory and motor coordination have been improved (P<0.001).Conclusion: Results suggest that ZINC CHLORIDE consumption with (30 mg/kg/day) dose, could have a significant effect on memory and motor coordination and could prevent the negative effect of AIC13on learning, memory and motor activity. Different mechanisms such as modulation of NMDA receptors and modulation of the entry of aluminum into the brain may be potentially involved in the observed effect of zinc.

Cites

No record.

References

No record.

Cite

APA: Copy

GHOTB ALDIN, Z., MOAZEDI, A.A., & PARHAM, GH.A.. (2007). EFFECT OF COMBINED ADMINISTRATION OF ZINC CHLORIDE AND ALUMINUM CHLORIDE ON MEMORY AND MOTOR ACTIVITY OF YOUNG RATS. PHYSIOLOGY AND PHARMACOLOGY, 11(2), 146-152. SID. https://sid.ir/paper/75152/en

Vancouver: Copy

GHOTB ALDIN Z., MOAZEDI A.A., PARHAM GH.A.. EFFECT OF COMBINED ADMINISTRATION OF ZINC CHLORIDE AND ALUMINUM CHLORIDE ON MEMORY AND MOTOR ACTIVITY OF YOUNG RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2007;11(2):146-152. Available from: https://sid.ir/paper/75152/en

IEEE: Copy

Z. GHOTB ALDIN, A.A. MOAZEDI, and GH.A. PARHAM, “EFFECT OF COMBINED ADMINISTRATION OF ZINC CHLORIDE AND ALUMINUM CHLORIDE ON MEMORY AND MOTOR ACTIVITY OF YOUNG RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 11, no. 2, pp. 146–152, 2007, [Online]. Available: https://sid.ir/paper/75152/en

Related Journal Papers