A COMPARATIVE STUDY ON THE EFFECT OF L-ARGININE AND MORPHINE IN INDUCTION OF CONDITIONED PLACE PREFERENCE IN RAT

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SAHRAIE H.; GHOSHOUNI H.; PIRZADEH JAHROMI ZHILA; ASGARI A.R.; POURHEYDARI GH.R.; KHOUSHBATEN A.

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Journal: Physiology and Pharmacology Year:2003 | Volume:7 | Issue:1 Page(s): 29-40

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Title

A COMPARATIVE STUDY ON THE EFFECT OF L-ARGININE AND MORPHINE IN INDUCTION OF CONDITIONED PLACE PREFERENCE IN RAT

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Keywords

L-ARGININEQ4

L-NAMEQ3

CPPQ4

DRUG REWARDQ4

VENTRAL TEGMENTAL AREAQ4

MORPHINEQ3

Abstract

It has been shown that L-ARGININE like the abused drugs could release dopamine from mesa-corrico-limbic system. The purpose of the present study was to compare the effect of L-ARGININE with MORPHINE as a standard abuse drug in induction of conditioned place preference (CPP) in rat. For this purpose, male Wistar rats (250-300 g) were used in the experiment. Five days after surgical cannulation in the VENTRAL TEGMENTAL AREA (VTA), different doses of L-ARGININE, L-NAME or MORPHINE were injected and conditioned biased method was preformed. The results showed that: 1. Intraperitoneal (i.p.) (0.1, 1 and 5 mg/kg) but not intra VTA (i-VTA) (0.3, 0.1 and 3 µg/rat) injections of L-ARGININE induced CPP in a dosedependent manner. Injection of 10 mg/kg (i.p.) and 2 µg/rat of MORPHINE (i-VTA) also caused a significant CPP in rats. Both i.p. (0.1, 1 and 5 mg/kg) and i-VIA (0.3, 0.1 and 3 µg/rat) injection of L-NAME did not produce any effect in the rats, but the drug at a higher dose (5 mg/kg, i.p.) attenuates the CPP induced by L-ARGININE (5 mg/kg, i.p.). Administration of MORPHINE (l0 mg/kg, i.p.) on three consecutive days and, then with av 3-day interval caused the occurrence of sensitization to MORPHINE, so that injection of , ineffective dose of MORPHINE (0.5 mg/kg, i.p.) induced CPP in sensitized rats. However, I when the procedure was repeated for L-ARGININE (5 mg/kg, i.p.), rats showed negative I response to the ineffective dose of L-ARGININE (0.1 mg/kg, i.p.). Meanwhile, in rats I which received L-ARGININE (5 mg/kg, i.p.) on training days, injection of the same dose of I L-ARGININE on "the test day dramatically decreased the time spent in drug-paired side, while injection of MORPHINE (10 mg/kg, i.p.) on the test day to those rats which have received MORPHINE (10 mg/kg, i.p.) on training days caused an increase in time spent in the drug-paired compartment. It could be concluded that i.p. injection of L-ARGININE causes significant CPP in rats and this behavior is attenuated by nitric oxide synthase inhibitor, L-NAME. Furthermore, the site of action of the drug seems not to be VTA. On the other hand, behaviors due to administration of L-ARGININE did not show some properties of abused drugs such as sensitization and state dependency.

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APA: Copy

SAHRAIE, H., GHOSHOUNI, H., PIRZADEH JAHROMI, ZHILA, ASGARI, A.R., POURHEYDARI, GH.R., & KHOUSHBATEN, A.. (2003). A COMPARATIVE STUDY ON THE EFFECT OF L-ARGININE AND MORPHINE IN INDUCTION OF CONDITIONED PLACE PREFERENCE IN RAT. PHYSIOLOGY AND PHARMACOLOGY, 7(1), 29-40. SID. https://sid.ir/paper/75163/en

Vancouver: Copy

SAHRAIE H., GHOSHOUNI H., PIRZADEH JAHROMI ZHILA, ASGARI A.R., POURHEYDARI GH.R., KHOUSHBATEN A.. A COMPARATIVE STUDY ON THE EFFECT OF L-ARGININE AND MORPHINE IN INDUCTION OF CONDITIONED PLACE PREFERENCE IN RAT. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2003;7(1):29-40. Available from: https://sid.ir/paper/75163/en

IEEE: Copy

H. SAHRAIE, H. GHOSHOUNI, ZHILA PIRZADEH JAHROMI, A.R. ASGARI, GH.R. POURHEYDARI, and A. KHOUSHBATEN, “A COMPARATIVE STUDY ON THE EFFECT OF L-ARGININE AND MORPHINE IN INDUCTION OF CONDITIONED PLACE PREFERENCE IN RAT,” PHYSIOLOGY AND PHARMACOLOGY, vol. 7, no. 1, pp. 29–40, 2003, [Online]. Available: https://sid.ir/paper/75163/en

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