THE EFFECT OF GABAERGIC RECEPTOR AGONISTS AND ANTAGONISTS ON THE EXPRESSION OF MORPHINE-INDUCED PLACE PREFERENCE IN MALE MICE

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JALILI C.; EBRAHIMI TEHRANI M.; FIROOZABADI H.; KHOUSHBATEN A.; ASGARI A.; GHOSHOUNI H.; SAHRAEI HEDAYAT; ZARINDAST M.R.

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Journal: Physiology and Pharmacology Year:2001 | Volume:5 | Issue:1 Page(s): 55-66

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Title

THE EFFECT OF GABAERGIC RECEPTOR AGONISTS AND ANTAGONISTS ON THE EXPRESSION OF MORPHINE-INDUCED PLACE PREFERENCE IN MALE MICE

Author(s)

Keywords

MORPHINEQ3

GABAQ4

CONDITIONED PLACE PREFERENCEQ4

MOUSEQ3

Abstract

MORPHINE can induce psychological dependence by blocking inhibitory GABAergic interneuron's in the mesolimbic dopaminergic pathway. Since the involvement of GABAergic receptor subtypes in this respect is not clear, therefore in this research study the possible role of GABAAand GABABreceptor subtypes on the expression of CONDITIONED PLACE PREFERENCE (CPP) in male Swiss-Webster mice were investigated. The results showed that GABAA receptor agonist muscimol, (0.15-1.2 mg/kg, i.p.) had no effect on MORPHINE action, while GABAA receptor competitive antagonist bicuculline, (0.75-1 mg/kg, i.p.) and GABAA receptor noncompetitive antagonist picrotoxin (2 mg/kg, i.p.) potentiated the expression of MORPHINE induced CPP. Baclofen, a GABAB receptor agonist (5 mg/kg, i.p.) reduced the expression of CPP induced by MORPHINE, while CGP 35348, a GABA Breceptor antagonist (2.5-400 mg/kg, i.p.) had no effect on MORPHINE action. Moreover, pretreatment with bicuculline (1 mg/kg, i.p.) or picrotoxin (2 mg/kg, i.p.) or CGP 35348 (400 mg/kg, i.p.) reverses the baclofen (5 mg/kg, p.) effect on the expression of MORPHINE-induced CPP. Pretreatment with both bicuculline (0.5 mg/kg, p.) and CGP 35348 (200 mg/kg, i.p.) compensated reducing effect of baclofen (5 mg/kg, i.p.) on the expression of orphine-induced CPP.In conclusion, it can be suggested that blockade of GABAA receptors might potentate the rewarding effect of MORPHINE, while activation of these receptors could attenuate the rewarding effect of MORPHINE. On the other hand, GABAc receptors might also strengthen the action of MORPHINE.

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APA: Copy

JALILI, C., EBRAHIMI TEHRANI, M., FIROOZABADI, H., KHOUSHBATEN, A., ASGARI, A., GHOSHOUNI, H., SAHRAEI, HEDAYAT, & ZARINDAST, M.R.. (2001). THE EFFECT OF GABAERGIC RECEPTOR AGONISTS AND ANTAGONISTS ON THE EXPRESSION OF MORPHINE-INDUCED PLACE PREFERENCE IN MALE MICE. PHYSIOLOGY AND PHARMACOLOGY, 5(1), 55-66. SID. https://sid.ir/paper/75244/en

Vancouver: Copy

JALILI C., EBRAHIMI TEHRANI M., FIROOZABADI H., KHOUSHBATEN A., ASGARI A., GHOSHOUNI H., SAHRAEI HEDAYAT, ZARINDAST M.R.. THE EFFECT OF GABAERGIC RECEPTOR AGONISTS AND ANTAGONISTS ON THE EXPRESSION OF MORPHINE-INDUCED PLACE PREFERENCE IN MALE MICE. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2001;5(1):55-66. Available from: https://sid.ir/paper/75244/en

IEEE: Copy

C. JALILI, M. EBRAHIMI TEHRANI, H. FIROOZABADI, A. KHOUSHBATEN, A. ASGARI, H. GHOSHOUNI, HEDAYAT SAHRAEI, and M.R. ZARINDAST, “THE EFFECT OF GABAERGIC RECEPTOR AGONISTS AND ANTAGONISTS ON THE EXPRESSION OF MORPHINE-INDUCED PLACE PREFERENCE IN MALE MICE,” PHYSIOLOGY AND PHARMACOLOGY, vol. 5, no. 1, pp. 55–66, 2001, [Online]. Available: https://sid.ir/paper/75244/en

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