THE EFFECT OF BACLOFEN ON GROWTH HORMONE, THYROXINE, AND TRIIODOTHYRONINE IN HOLSTEIN COWS

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KHAKPAY R.; KHAZALI H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2003 | Volume:7 | Issue:1 Page(s): 89-94

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Information Journal Paper

Title

THE EFFECT OF BACLOFEN ON GROWTH HORMONE, THYROXINE, AND TRIIODOTHYRONINE IN HOLSTEIN COWS

Author(s)

KHAKPAY R. | KHAZALI H. | Issue Writer Certificate

Keywords

GABAQ4

BACLOFENQ4

GROWTH HORMONEQ3

THYROXINEQ4

TRIIODOTHYRONINEQ4

Abstract

In this research study, the effect of bac10fen (GAB AB receptor agonist) on mean concentration of GROWTH HORMONE, THYROXINE, and TRIIODOTHYRONINE was examined. For this purpose, twelve Holstein cows were divided into four groups. Then, each cow received daily injection of 25, 50, 75, and 100 mg/kg of BACLOFEN for a period of four days. Blood samples were daily collected at one time point for eight days. GROWTH HORMONE, THYROXINE, and TRIIODOTHYRONINE concentrations of plasma samples were measured by RIA (Radioimmunoassay) method. The results showed that BACLOFEN increases mean plasma concentration of GROWTH HORMONE and THYROXINE (P<0.01). In addition, low doses of bac10fen decreased mean plasma concentration of TRIIODOTHYRONINE (P<0.05), while 100 mg/kg of BACLOFEN increased mean plasma concentration of TRIIODOTHYRONINE (P<0.05).

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