THE EFFECT OF INJECTION OF ESTRADIOL BENZOATE INTO HIPPOCAMPAL CA1 AREA ON SPATIAL LEARNING AND MEMORY IN INTACT AND CASTRATED ADULT MALE RATS

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MOAZEDI A.A.; HOVEYDA R.; RASEKH A.

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Paper Information

Journal: Physiology and Pharmacology Year:2003 | Volume:7 | Issue:1 Page(s): 73-89

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Information Journal Paper

Title

THE EFFECT OF INJECTION OF ESTRADIOL BENZOATE INTO HIPPOCAMPAL CA1 AREA ON SPATIAL LEARNING AND MEMORY IN INTACT AND CASTRATED ADULT MALE RATS

Author(s)

MOAZEDI A.A. | HOVEYDA R. | RASEKH A. | Issue Writer Certificate

Keywords

SPATIAL LEARNING AND MEMORYQ3

ESTRADIOLQ4

INTRAHIPPOCAMPALQ4

CA1Q4

Y-MAZEQ4

Abstract

Estrogen has a widespread and complex influence on brain capabilities such as learning and memory. On the other hand, hippocampus as one of the main brain structures has an important role in spatial information processing. There is some evidence on the existence of estrogen receptors in the hippocampal CA1 area. So, in this study the effect of INTRAHIPPOCAMPAL injection of ESTRADIOL benzoate on SPATIAL LEARNING AND MEMORY were investigated in intact and castrated adult male NMRI rats The animals were randomly divided into eight groups and bilaterally cannulated (n=7). The intact and castrated control groups (no injection) were only trained in Y-MAZE. The castrated and intact rats received sesame oil vehicle, sham physiological saline and ESTRADIOL. Test groups received bilaterally 0.5 µl of sesame oil, 0.5 µl of physiological saline, and 1 µg/0.5 µl of ESTRADIOL benzoate respectively into the CA1 region of hippocampus immediately before training. Then, each rat was trained in 30 trials every day for a total of 5 days with Y-MAZE. After one month, all of the groups were again tested (one session) for memory performance. Statistical analysis of data showed that ESTRADIOL increases spatial learning in both castrated and intact groups. There was also no significant difference between castrated and intact groups regarding memory performance. In conclusion, it seems that ESTRADIOL increases spatial learning task through an interaction with cholinergic system and an enhancement of synaptic plasticity in CA1 region.

Cites

ZINC IMPAIRS LEARNING AND MEMORY BY MODULATING NMDA RECEPTORS IN HIPPOCAMPAL CA1 REGION IN RATS

References

مقایسه یادگیری فضایی در موش های صحرایی نر و ماده با استفاده از دستگاه Y-maze کامپیوتری

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APA: Copy

MOAZEDI, A.A., HOVEYDA, R., & RASEKH, A.. (2003). THE EFFECT OF INJECTION OF ESTRADIOL BENZOATE INTO HIPPOCAMPAL CA1 AREA ON SPATIAL LEARNING AND MEMORY IN INTACT AND CASTRATED ADULT MALE RATS. PHYSIOLOGY AND PHARMACOLOGY, 7(1), 73-89. SID. https://sid.ir/paper/75168/en

Vancouver: Copy

MOAZEDI A.A., HOVEYDA R., RASEKH A.. THE EFFECT OF INJECTION OF ESTRADIOL BENZOATE INTO HIPPOCAMPAL CA1 AREA ON SPATIAL LEARNING AND MEMORY IN INTACT AND CASTRATED ADULT MALE RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2003;7(1):73-89. Available from: https://sid.ir/paper/75168/en

IEEE: Copy

A.A. MOAZEDI, R. HOVEYDA, and A. RASEKH, “THE EFFECT OF INJECTION OF ESTRADIOL BENZOATE INTO HIPPOCAMPAL CA1 AREA ON SPATIAL LEARNING AND MEMORY IN INTACT AND CASTRATED ADULT MALE RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 7, no. 1, pp. 73–89, 2003, [Online]. Available: https://sid.ir/paper/75168/en

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