THE EFFECT OF INTRAHIPPOCAMPAL CA1 AREA INJECTION OF ESTRADIOL BENZOATE ON THE SPATIAL LEARNING AND MEMORY IN ADULT MALE RATS

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HOVEIDA R.I.; MOAZEDI A.A.; RASEKH A.

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Journal: Pathobiology Research Year:2005 | Volume:7 | Issue:2 Page(s): 115-124

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Title

THE EFFECT OF INTRAHIPPOCAMPAL CA1 AREA INJECTION OF ESTRADIOL BENZOATE ON THE SPATIAL LEARNING AND MEMORY IN ADULT MALE RATS

Author(s)

HOVEIDA R.I. | MOAZEDI A.A. | RASEKH A. | Issue Writer Certificate

Keywords

SPATIAL LEARNING AND MEMORYQ3

ESTRADIOL BENZOATEQ4

HIPPOCAMPUS CAI AREAQ4

Y-MAZEQ4

INTRAHIPPOCAMPAL INJECTIONQ4

Abstract

Purpose: Estrogen has a vast and complex role upon brain abilities such as learining and memory. On the other hand, hippocampus, as one of the brain structures, has an important role in spatial information processing. Some evidences indicate that there is estrogen receptors in the hippocampal CAl area. So, in this study the effect of intera hippocamp1 injection of estradio1 benzoate on the SPATIAL LEARNING AND MEMORY in N-MRI adult male rats was investigated.Materials and Methods: The animals were bilaterally microcannulated into the following 4 groups (n=7).The control group (no injection) were only trained in a Y-MAZE. The sesame oil vehicle, physiological saline sham and estradiol test groups which received bilateral 0.5µ1 sesame oil, 0.5µ1 physiological saline and 1µg/0.5µ1 ESTRADIOL BENZOATE respectively, into the CA1 region of the hippocampus immediately before training. Then, each rat was trained in 30 trials every day for a total of 5 days with the Y-MAZE and after one month all of the groups were tested (one session) for the memory test. Results: Statistical analysis of the data using the repeated measure design and the least significant differences between the learning results after 5 days of training in different groups indicated a chang in the animal memories.Conclution: It seems that the estradiol increases the spatial learning task. through the enhancement in synaptic plasticity in hippocampal CA1 region neurones.Keywords: SPATIAL LEARNING AND MEMORY, ESTRADIOL BENZOATE, HIPPOCAMPUS CAI AREA, Y-MAZE, INTRAHIPPOCAMPAL INJECTION.

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References

THE EFFECTS OF CORN OIL ON SPATIAL LEARNING IN RAT

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APA: Copy

HOVEIDA, R.I., MOAZEDI, A.A., & RASEKH, A.. (2005). THE EFFECT OF INTRAHIPPOCAMPAL CA1 AREA INJECTION OF ESTRADIOL BENZOATE ON THE SPATIAL LEARNING AND MEMORY IN ADULT MALE RATS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 7(2), 115-124. SID. https://sid.ir/paper/81157/en

Vancouver: Copy

HOVEIDA R.I., MOAZEDI A.A., RASEKH A.. THE EFFECT OF INTRAHIPPOCAMPAL CA1 AREA INJECTION OF ESTRADIOL BENZOATE ON THE SPATIAL LEARNING AND MEMORY IN ADULT MALE RATS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2005;7(2):115-124. Available from: https://sid.ir/paper/81157/en

IEEE: Copy

R.I. HOVEIDA, A.A. MOAZEDI, and A. RASEKH, “THE EFFECT OF INTRAHIPPOCAMPAL CA1 AREA INJECTION OF ESTRADIOL BENZOATE ON THE SPATIAL LEARNING AND MEMORY IN ADULT MALE RATS,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 7, no. 2, pp. 115–124, 2005, [Online]. Available: https://sid.ir/paper/81157/en

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