مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

127
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

104
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Selenium-L-methionine modulates radiation injury and Duox1 and Duox2 upregulation in rat’ s heart tissues

Pages

  121-126

Abstract

 Introduction: Redox interactions play a key role in Radiation injury including Heart diseases. In present study, we aimed to detect the possible protective role of Selenium-L-Methionine on infiltration of immune cells and Duox1&2 upregulation in rat’ s Heart tissues. Methods: In this study, 20 rats were divided into 4 groups (5 rats in each) namely: irRadiation; irRadiation plus Selenium-L-Methionine; control; and Selenium-L-Methionine treatment. IrRadiation (15 Gy to chest) was performed using a cobalt-60 gamma ray source while 4 mg/kg of Selenium-L-Methionine was administered intraperitoneally. Ten weeks after irRadiation, rats were sacrificed for detection of IL-4 and IL-13 cytokines, infiltration of macrophages and lymphocytes as well as the expressions of IL4Ra1, Duox1, IL13Ra2 and Duox2. Results: Results showed an increase in the level of IL-4 as well as the expressions of IL4Ra1, Duox1 and Duox2. Similarly, there was an increase in the infiltration of lymphocytes and macrophages. There was significant attenuation of all these changes following treatment with selenium-Lmethionine. Conclusion: Selenium-L-Methionine has the potential to protect Heart tissues against Radiation injury. Downregulation of pro-oxidant genes and modulation of some cytokines such as IL-4 are involved in the radioprotective effect of Selenium-L-Methionine on Heart tissues.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Kolivand, Sedighe, AMINI, PEYMAN, SAFFAR, HANA, Rezapoor, Saeed, NAJAFI, MASOUD, MOTEVASELI, ELAHE, Nouruzi, Farzad, Shabeeb, Dheyauldeen, & Eleojo Musa, Ahmed. (2019). Selenium-L-methionine modulates radiation injury and Duox1 and Duox2 upregulation in rat’ s heart tissues. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, 11(2), 121-126. SID. https://sid.ir/paper/751987/en

    Vancouver: Copy

    Kolivand Sedighe, AMINI PEYMAN, SAFFAR HANA, Rezapoor Saeed, NAJAFI MASOUD, MOTEVASELI ELAHE, Nouruzi Farzad, Shabeeb Dheyauldeen, Eleojo Musa Ahmed. Selenium-L-methionine modulates radiation injury and Duox1 and Duox2 upregulation in rat’ s heart tissues. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH[Internet]. 2019;11(2):121-126. Available from: https://sid.ir/paper/751987/en

    IEEE: Copy

    Sedighe Kolivand, PEYMAN AMINI, HANA SAFFAR, Saeed Rezapoor, MASOUD NAJAFI, ELAHE MOTEVASELI, Farzad Nouruzi, Dheyauldeen Shabeeb, and Ahmed Eleojo Musa, “Selenium-L-methionine modulates radiation injury and Duox1 and Duox2 upregulation in rat’ s heart tissues,” JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, vol. 11, no. 2, pp. 121–126, 2019, [Online]. Available: https://sid.ir/paper/751987/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button