THE EFFECT OF INTRAPERITONEAL INJECTION OF N6-CYCLOHEXYLADENOSINE, A SELECTIVE ADENOSINE A1 RECEPTOR AGONIST, ON ENTORHINAL CORTEX-KINDLED SEIZURES IN RATS

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AMINI KOMIJANI A.; MIRNAJAFIZADEH S.J.; FATH ELAHI Y.; ANAYI GODARI A.; MOHAMMADZADEH M.

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Journal: Physiology and Pharmacology Year:2004 | Volume:7 | Issue:2 Page(s): 97-106

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Title

THE EFFECT OF INTRAPERITONEAL INJECTION OF N6-CYCLOHEXYLADENOSINE, A SELECTIVE ADENOSINE A1 RECEPTOR AGONIST, ON ENTORHINAL CORTEX-KINDLED SEIZURES IN RATS

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Keywords

SEIZUREQ3

KINDLINGQ3

ENTORHINAL CORTEXQ4

ADENOSINEQ3

Abstract

The effects of intraperitoneal injection of N6-cyclohexyladenosine (CHA, a selective ADENOSINE A1 receptor agonist) and 8-cyclopenthyle-l-3-dimethylexanthine (CPT, a selective ADENOSINE A1 receptor antagonist) on ENTORHINAL CORTEX-kindled SEIZUREs were investigated. Fully ENTORHINAL CORTEX-kindled rats received normal saline (control), CHA (0.06, 0.12 and 0.25 mg/kg) or CPT (0.06 and 0.12 mg/kg) and 15 min later were stimulated at AD threshold. Obtained data showed that intraperitoneal administration of CHA (0.12 and 0.25 mg/kg) reduces ENTORHINAL CORTEX afterdischarge duration (ADD), duration of stage 5 of the SEIZURE (S5D) and SEIZURE duration (SD) at 15 min post-drug injection. The latency for stage 4 of the SEIZURE (S4L) also increased at these doses. At the dose of 0.06 mg/kg, CHA only reduced S5D. lntraperitoneal injection of CPT increased ADD only at 0.12 mg/kg, but not at 0.06 mg/kg. Pretreatment of animals with CPT (0.06 mg/kg), 5 min before CHA (0.12 mg/kg) blocked the anticonvulsant effects of CHA. Obtained results may indicate that activity of ADENOSINE A1 receptors reduces the severity of ENTORHINAL CORTEX-kindled SEIZUREs.

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APA: Copy

AMINI KOMIJANI, A., MIRNAJAFIZADEH, S.J., FATH ELAHI, Y., ANAYI GODARI, A., & MOHAMMADZADEH, M.. (2004). THE EFFECT OF INTRAPERITONEAL INJECTION OF N6-CYCLOHEXYLADENOSINE, A SELECTIVE ADENOSINE A1 RECEPTOR AGONIST, ON ENTORHINAL CORTEX-KINDLED SEIZURES IN RATS. PHYSIOLOGY AND PHARMACOLOGY, 7(2), 97-106. SID. https://sid.ir/paper/75206/en

Vancouver: Copy

AMINI KOMIJANI A., MIRNAJAFIZADEH S.J., FATH ELAHI Y., ANAYI GODARI A., MOHAMMADZADEH M.. THE EFFECT OF INTRAPERITONEAL INJECTION OF N6-CYCLOHEXYLADENOSINE, A SELECTIVE ADENOSINE A1 RECEPTOR AGONIST, ON ENTORHINAL CORTEX-KINDLED SEIZURES IN RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2004;7(2):97-106. Available from: https://sid.ir/paper/75206/en

IEEE: Copy

A. AMINI KOMIJANI, S.J. MIRNAJAFIZADEH, Y. FATH ELAHI, A. ANAYI GODARI, and M. MOHAMMADZADEH, “THE EFFECT OF INTRAPERITONEAL INJECTION OF N6-CYCLOHEXYLADENOSINE, A SELECTIVE ADENOSINE A1 RECEPTOR AGONIST, ON ENTORHINAL CORTEX-KINDLED SEIZURES IN RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 7, no. 2, pp. 97–106, 2004, [Online]. Available: https://sid.ir/paper/75206/en

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