EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF OLIVE LEAF EXTRACT ON PTZ-INDUCED SEIZURES IN MALE RATS

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ZENDEHDEL MORTEZA; KERAMATI KEYVAN; GARAVAND SEDIGHEH

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Journal: Physiology and Pharmacology Year:2011 | Volume:15 | Issue:1 Page(s): 108-115

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Title

EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF OLIVE LEAF EXTRACT ON PTZ-INDUCED SEIZURES IN MALE RATS

Author(s)

ZENDEHDEL MORTEZA | KERAMATI KEYVAN | GARAVAND SEDIGHEH | Issue Writer Certificate

Keywords

EPILEPSYQ3

OLIVE-LEAF EXTRACTQ2

PTZQ2

Abstract

Introduction: Olive leaf contains anti-inflammatory and COX-2 inhibitor compounds. Considering the role of the COX enzyme in seizures, this research was performed to assess the effects of this extract in treatment of seizures induced by PTZ.Methods: In this research, male Wistar rats (200±20 g) were injected intra-cerebroventricularly with 1 ml saline or olive leaf extract (125 mg, 250 mg and 500 mg), before the intraperitoneal administration of PTZ (80 mg/kg) for induction of seizure. Then, seizure score and onset times of every stage of seizure were recorded during 20 minutes after PTZ administration. The data was analyzed by one-way analysis of variance (ANOVA) and non parametric tests.Results: Result of this research showed that the injection of 125, 250 and 500 mg of olive leaf extract had no effect on the onset time of seizure stages 1, 2 and 3 compared to the control group (P>0.05). However, they significantly decreased the onset time of seizure stages 4 and 5 compared to the control group (P<0.05). On the other hand, olive leaf extract decreased onset time of generalized (tonic-clonic) seizures, but had no effect on partial seizures. Different doses of olive leaf extract had no effect on seizure scores.Conclusion: Olive leaf extract has convulsive property and this effect is time and dose dependent.

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APA: Copy

ZENDEHDEL, MORTEZA, KERAMATI, KEYVAN, & GARAVAND, SEDIGHEH. (2011). EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF OLIVE LEAF EXTRACT ON PTZ-INDUCED SEIZURES IN MALE RATS. PHYSIOLOGY AND PHARMACOLOGY, 15(1), 108-115. SID. https://sid.ir/paper/75217/en

Vancouver: Copy

ZENDEHDEL MORTEZA, KERAMATI KEYVAN, GARAVAND SEDIGHEH. EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF OLIVE LEAF EXTRACT ON PTZ-INDUCED SEIZURES IN MALE RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2011;15(1):108-115. Available from: https://sid.ir/paper/75217/en

IEEE: Copy

MORTEZA ZENDEHDEL, KEYVAN KERAMATI, and SEDIGHEH GARAVAND, “EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF OLIVE LEAF EXTRACT ON PTZ-INDUCED SEIZURES IN MALE RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 15, no. 1, pp. 108–115, 2011, [Online]. Available: https://sid.ir/paper/75217/en

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