ELECTROPHYSIOLOGICAL CHARACTERISTICS OF HIPPOCAMPAL CA1 NEURONS AFTER SPREADING DEPRESSION-TRIGGERED EPILEPTIC ACTIVITY IN BRAIN SLICES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAHABI PARVIZ; GORJI ALI; JANAHMADI MAHYAR; MIRNAJAFI ZADEH JAVAD; ARABKHERADMAND JALIL; ALEXANDER EICKHOFF MARIUS

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2011 | Volume:15 | Issue:1 Page(s): 1-15

Download Full-Text

Persian Verion

View:

1,056

Download:

Cites:

Information Journal Paper

Title

ELECTROPHYSIOLOGICAL CHARACTERISTICS OF HIPPOCAMPAL CA1 NEURONS AFTER SPREADING DEPRESSION-TRIGGERED EPILEPTIC ACTIVITY IN BRAIN SLICES

Author(s)

Keywords

EPILEPSYQ3

HORIZONTAL SLICESQ2

SPREADING DEPRESSIONQ2

ICTAL BURST ACTIVITYQ2

BICUCULLINEQ3

Abstract

Introduction: A close link between SPREADING DEPRESSION (SD) and several neurological diseases such as EPILEPSY could be demonstrated in many experimental studies. EPILEPSY is among the most common brain disorders. Despite a large number of investigations, its mechanisms have not been yet well elucidated. Hippocampus is one of the important structures involved in seizures. The aim of this study is to get an insight into the patho-physiological processes induced by SD that lead to the generation of epileptiform field potentials.Methods: The horizontal amygdala-hippocampus-neocortex slices of rat brain in which SD was induced by KCl application in each brain structure were used. Following GABAA receptor antagonist BICUCULLINE superfusion (1.25mmol/L, for 45 min), SD induced epileptic activity in all tested slices was monitored.Results: The induction of SD in the hippocampus resulted in interictal and ictal epileptiform field potentials and intracellular paroxysmal depolarization shifts (PDS). After SD, RMP slightly depolarized and the threshold of AP decreased, while the frequency of AP significantly increased. Amplitude of depolarization and also amplitude of discharges were also significantly increased. ISI significantly decreased and the most of neurons shifted from FA to SA indicating an enhanced excitability.Conclusion: SD may cause pathological changes in brain structures such as increased excitation and/or decreased inhibition. Propagation of SD over epileptogenic areas may trigger seizure attacks in some patients and our findings provide evidence on the role of SD in temporal lobe EPILEPSY.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAHABI, PARVIZ, GORJI, ALI, JANAHMADI, MAHYAR, MIRNAJAFI ZADEH, JAVAD, ARABKHERADMAND, JALIL, & ALEXANDER EICKHOFF, MARIUS. (2011). ELECTROPHYSIOLOGICAL CHARACTERISTICS OF HIPPOCAMPAL CA1 NEURONS AFTER SPREADING DEPRESSION-TRIGGERED EPILEPTIC ACTIVITY IN BRAIN SLICES. PHYSIOLOGY AND PHARMACOLOGY, 15(1), 1-15. SID. https://sid.ir/paper/75219/en

Vancouver: Copy

SHAHABI PARVIZ, GORJI ALI, JANAHMADI MAHYAR, MIRNAJAFI ZADEH JAVAD, ARABKHERADMAND JALIL, ALEXANDER EICKHOFF MARIUS. ELECTROPHYSIOLOGICAL CHARACTERISTICS OF HIPPOCAMPAL CA1 NEURONS AFTER SPREADING DEPRESSION-TRIGGERED EPILEPTIC ACTIVITY IN BRAIN SLICES. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2011;15(1):1-15. Available from: https://sid.ir/paper/75219/en

IEEE: Copy

PARVIZ SHAHABI, ALI GORJI, MAHYAR JANAHMADI, JAVAD MIRNAJAFI ZADEH, JALIL ARABKHERADMAND, and MARIUS ALEXANDER EICKHOFF, “ELECTROPHYSIOLOGICAL CHARACTERISTICS OF HIPPOCAMPAL CA1 NEURONS AFTER SPREADING DEPRESSION-TRIGGERED EPILEPTIC ACTIVITY IN BRAIN SLICES,” PHYSIOLOGY AND PHARMACOLOGY, vol. 15, no. 1, pp. 1–15, 2011, [Online]. Available: https://sid.ir/paper/75219/en

Related Journal Papers