RESPONSIVENESS OF BETA-2 ADRENOCEPTORS OF DIABETIC RAT KNEE JOINT BLOOD VESSELS DECREASE OF IN ACUTE INFLAMMATION

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HAJIZADEH S.; ERFANI B.; FAGHIHI S.M.; BARABADI Z.; HOSSEINI MARZIEH

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Journal: Physiology and Pharmacology Year:2008 | Volume:12 | Issue:3 Page(s): 221-226

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Title

RESPONSIVENESS OF BETA-2 ADRENOCEPTORS OF DIABETIC RAT KNEE JOINT BLOOD VESSELS DECREASE OF IN ACUTE INFLAMMATION

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Keywords

DIABETESQ2

ACUTE INFLAMMATIONQ4

BETA-2 ADRENOCEPTORSQ3

KNEE JOINTQ3

Abstract

Introduction: BETA-2 ADRENOCEPTORS are important in blood flow regulation. Responsiveness of these receptors is decreased in diabetic angiopathy, in contrast to inflammation, where this responsiveness is increased. Considering these opposite effects, the aim of this study was to investigate the vasodilatory response of KNEE JOINT blood vessels to salbutamol (a Beta-2 adrenoceptor agonist) in inflamedjoints of diabetic rats.Methods: Acute KNEE JOINT inflammation was induced by intraarticular injection of kaolin 4% and induction of DIABETES was performed by streptozotocin (55 mg/kg). Wistar rats weighting 200-300 g were used. The animals were divided in 5 groups; control, saline, diabetic, inflammatory and diabetic-inflammatory. Blood flow of KNEE JOINT was measured using laser Doppler flowmeter technique (LDF). Vasodilatation of articular micro vasculature was measured in response to topical application of different concentration of salbutamol (10 -11-10 -1 M). Results: Data obtained in this study showed that: 1- ACUTE INFLAMMATION caused significantly less increments in KNEE JOINT diameter and perimeter in diabetic compared to non-diabetic rats. 2- Responsiveness ofBeta-2 adrenoceptors was increased in kaolin-induced ACUTE INFLAMMATION in non-diabetic rats. 3- In diabetic rats, kaolin-induced ACUTE INFLAMMATION could not increase the responsiveness ofBeta-2 adrenoceptors.Conclusion: We conclude that DIABETES inhibits the increasing effects of ACUTE INFLAMMATION on responsiveness of BETA-2 ADRENOCEPTORS.

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APA: Copy

HAJIZADEH, S., ERFANI, B., FAGHIHI, S.M., BARABADI, Z., & HOSSEINI, MARZIEH. (2008). RESPONSIVENESS OF BETA-2 ADRENOCEPTORS OF DIABETIC RAT KNEE JOINT BLOOD VESSELS DECREASE OF IN ACUTE INFLAMMATION . PHYSIOLOGY AND PHARMACOLOGY, 12(3), 221-226. SID. https://sid.ir/paper/75236/en

Vancouver: Copy

HAJIZADEH S., ERFANI B., FAGHIHI S.M., BARABADI Z., HOSSEINI MARZIEH. RESPONSIVENESS OF BETA-2 ADRENOCEPTORS OF DIABETIC RAT KNEE JOINT BLOOD VESSELS DECREASE OF IN ACUTE INFLAMMATION . PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2008;12(3):221-226. Available from: https://sid.ir/paper/75236/en

IEEE: Copy

S. HAJIZADEH, B. ERFANI, S.M. FAGHIHI, Z. BARABADI, and MARZIEH HOSSEINI, “RESPONSIVENESS OF BETA-2 ADRENOCEPTORS OF DIABETIC RAT KNEE JOINT BLOOD VESSELS DECREASE OF IN ACUTE INFLAMMATION ,” PHYSIOLOGY AND PHARMACOLOGY, vol. 12, no. 3, pp. 221–226, 2008, [Online]. Available: https://sid.ir/paper/75236/en

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