EMBRYONIC STEM CELLS DERIVED CARDIOMYOCYTES ARE A SUITABLE MODEL FOR ASSESSMENT OF CARDIOTOXIC EFFECTS OF DOXORUBICIN AND OTHER DRUGS

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FAROKHPOUR M.; KARBALAEI KH.; ETEBARI M.; MIRMOHAMMAD SADEGHI HAMID; NEMAT ELAHI M.; NASRESFAHANI MOHAMMAD HOSSEIN; BAHARVAND HOSSEIN

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Journal: Physiology and Pharmacology Year:2008 | Volume:12 | Issue:3 Page(s): 238-244

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Title

EMBRYONIC STEM CELLS DERIVED CARDIOMYOCYTES ARE A SUITABLE MODEL FOR ASSESSMENT OF CARDIOTOXIC EFFECTS OF DOXORUBICIN AND OTHER DRUGS

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Keywords

STEM CELLQ2

CARDIOMYOCYTEQ3

DOXORUBICINQ2

DEXAMETHASONEQ3

Abstract

Introduction: DOXORUBICIN is frequently used for treatment of several types of cancer, but cardiac toxicity has limited the use of this drug. Corticosteroids may prevent DOXORUBICIN induced cardiotoxicity. Therefore the aim of this study was to evaluate mouse embryonic STEM CELLs derived CARDIOMYOCYTEs as a model to assess the effects of DOXORUBICIN and DEXAMETHASONE.Methods: Mouse embryonic STEM CELLs derived CARDIOMYOCYTEs were treated with different concentrations of DOXORUBICIN for 24 hours and the results were compared with control group. In order to examine the effect of DEXAMETHASONE on cardiotoxicity, mouse embryonic STEM CELLs derived CARDIOMYOCYTEs were either exposed to 0.1, 1 or 10 mM DEXAMETHASONE 24 hours prior to exposure to DOXORUBICIN or exposed to DEXAMETHASONE 24 hours before and during exposure to DOXORUBICIN. Each group was compared with cells that were treated with only DOXORUBICIN or DEXAMETHASONE.Results: 5 mM DOXORUBICIN was selected as the lowest dose that ceased heart beats in more than 50% of mouse embryonic STEM CELLs derived CARDIOMYOCYTEs. Results revealed that 10 mM DEXAMETHASONE for 24 hours before treatment with DOXORUBICIN has protective effect on DOXORUBICIN induced cardiotoxicity.Conclusion: The overall results obtained in this model are in accordance with previous literature. Thus suggesting that mouse embryonic STEM CELLs derived CARDIOMYOCYTEs is a suitable model for assessment of cardiotoxic effects of drugs.

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APA: Copy

FAROKHPOUR, M., KARBALAEI, KH., ETEBARI, M., MIRMOHAMMAD SADEGHI, HAMID, NASRESFAHANI, MOHAMMAD HOSSEIN, NEMAT ELAHI, M., & BAHARVAND, HOSSEIN. (2008). EMBRYONIC STEM CELLS DERIVED CARDIOMYOCYTES ARE A SUITABLE MODEL FOR ASSESSMENT OF CARDIOTOXIC EFFECTS OF DOXORUBICIN AND OTHER DRUGS . PHYSIOLOGY AND PHARMACOLOGY, 12(3), 238-244. SID. https://sid.ir/paper/75239/en

Vancouver: Copy

FAROKHPOUR M., KARBALAEI KH., ETEBARI M., MIRMOHAMMAD SADEGHI HAMID, NASRESFAHANI MOHAMMAD HOSSEIN, NEMAT ELAHI M., BAHARVAND HOSSEIN. EMBRYONIC STEM CELLS DERIVED CARDIOMYOCYTES ARE A SUITABLE MODEL FOR ASSESSMENT OF CARDIOTOXIC EFFECTS OF DOXORUBICIN AND OTHER DRUGS . PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2008;12(3):238-244. Available from: https://sid.ir/paper/75239/en

IEEE: Copy

M. FAROKHPOUR, KH. KARBALAEI, M. ETEBARI, HAMID MIRMOHAMMAD SADEGHI, MOHAMMAD HOSSEIN NASRESFAHANI, M. NEMAT ELAHI, and HOSSEIN BAHARVAND, “EMBRYONIC STEM CELLS DERIVED CARDIOMYOCYTES ARE A SUITABLE MODEL FOR ASSESSMENT OF CARDIOTOXIC EFFECTS OF DOXORUBICIN AND OTHER DRUGS ,” PHYSIOLOGY AND PHARMACOLOGY, vol. 12, no. 3, pp. 238–244, 2008, [Online]. Available: https://sid.ir/paper/75239/en

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