THE ROLE OF OXYGEN FREE RADICALS IN REPERFUSION INJURY

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KADKHODAEI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Physiology and Pharmacology Year:2001 | Volume:5 | Issue:1 Page(s): 97-105

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Information Journal Paper

Title

THE ROLE OF OXYGEN FREE RADICALS IN REPERFUSION INJURY

Author(s)

KADKHODAEI M. | Issue Writer Certificate

Keywords

ISCHEMIAQ3

REPERFUSIONQ4

OXYGEN FREE RADICALSQ3

CELLULAR INJURYQ4

Abstract

There have been many reports on the involvement of oxygen-derived free radicals (OFR) in the pathogenesis of REPERFUSION injury (RI). To determine the role of OFR in RI, the first evidence was based on the indirect methods obtained from the beneficial effects of antioxidants during post-ischemic REPERFUSION In some studies, OFR are detected locally and chemical production of OFR reproduces cellular dysfunction similar to that observed during ischaemia-reperfusion injury. Using of new techniques for direct detection and quantitation of these radicals showed their burst generation during first seconds of REPERFUSION.Several factors are implicated in the pathogenesis of RI including endothelial cells, endothelin, nitric oxide, cytokines, and neutrophils. The interaction of OFR with these factors makes RI more complicated. Therefore, knowledge of the mechanisms involved in the pathophysiology of REPERFUSION injury is clinically very significant to prevent the occurrence of RI.In this review, the cellular changes during ISCHEMIA and REPERFUSION and the possible role of OFR in these changes are to be discussed. It is worth mentioning that the involvement of OFR in tissue injury is still under intensive investigation.

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APA: Copy

KADKHODAEI, M.. (2001). THE ROLE OF OXYGEN FREE RADICALS IN REPERFUSION INJURY. PHYSIOLOGY AND PHARMACOLOGY, 5(1), 97-105. SID. https://sid.ir/paper/75248/en

Vancouver: Copy

KADKHODAEI M.. THE ROLE OF OXYGEN FREE RADICALS IN REPERFUSION INJURY. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2001;5(1):97-105. Available from: https://sid.ir/paper/75248/en

IEEE: Copy

M. KADKHODAEI, “THE ROLE OF OXYGEN FREE RADICALS IN REPERFUSION INJURY,” PHYSIOLOGY AND PHARMACOLOGY, vol. 5, no. 1, pp. 97–105, 2001, [Online]. Available: https://sid.ir/paper/75248/en

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