THE ROLE OF OXYGEN RADICALS-SCAVENGER IN NEUROPROTECTION-INDUCED BY NORMOBARIC HYPEROXIA ON INFARCT VOLUME IN THE RAT BRAIN

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ASHEGHABADI MAHDIYE; BIGDELI MOHAMMAD REZA

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Journal: Pathobiology Research Year:2011 | Volume:14 | Issue:2 Page(s): 75-82

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Title

THE ROLE OF OXYGEN RADICALS-SCAVENGER IN NEUROPROTECTION-INDUCED BY NORMOBARIC HYPEROXIA ON INFARCT VOLUME IN THE RAT BRAIN

Author(s)

ASHEGHABADI MAHDIYE | BIGDELI MOHAMMAD REZA | Issue Writer Certificate

Keywords

NEUROPROTECTIONQ2

STROKEQ2

NORMOBARIC HYPEROXIAQ2

NEUROLOGIC DEFICITQ2

FREE RADICAL OXYGENQ3

Abstract

Objective: Recent studies have shown that the use of prolonged and intermittent NORMOBARIC HYPEROXIA (95%) decrease the infarct volume of STROKE. The aim of current study was to study the effect of an oxygen radicals-scavenger applied during intermittent NORMOBARIC HYPEROXIA on infarct volume in the rat brain and NEUROLOGIC DEFICIT.Materials and Methods: Male Wistar rats (250-350 g) were divided to two main groups. These groups were respectively subjected to room air (21% O2; RA) or NORMOBARIC HYPEROXIA (95% O2; HO) 4 hours per day for 6 days. Each main group was divided to three subgroups which received nothing (RA and HO), normal saline (HO-S and RA-S) or Dimethyltiourea (HO-MT and RA-MT. Afterward, all rats were subjected to 60 min middle cerebral artery occlusion (MCAO). After 24 h, NEUROLOGIC DEFICIT scores and infarct volume were assessed.Results: The medians of NEUROLOGIC DEFICIT scores in RA, RA-MT, RA-S, HO-MT, HO-S, and HO were 2, 2, 2, 2, 0, 0, respectively. The infarct volume in RA, RA-MT, RA-S, and HO-MT versus HO-S, and HO were increased. Above results showed that NEUROLOGIC DEFICIT score and infarct volume were restored by MT significantly.Conclusion: The effective NEUROPROTECTION induced by intermittent NORMOBARIC HYPEROXIA seems to be mediated at least partially by oxygen radicals.

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APA: Copy

ASHEGHABADI, MAHDIYE, & BIGDELI, MOHAMMAD REZA. (2011). THE ROLE OF OXYGEN RADICALS-SCAVENGER IN NEUROPROTECTION-INDUCED BY NORMOBARIC HYPEROXIA ON INFARCT VOLUME IN THE RAT BRAIN. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 14(2), 75-82. SID. https://sid.ir/paper/81313/en

Vancouver: Copy

ASHEGHABADI MAHDIYE, BIGDELI MOHAMMAD REZA. THE ROLE OF OXYGEN RADICALS-SCAVENGER IN NEUROPROTECTION-INDUCED BY NORMOBARIC HYPEROXIA ON INFARCT VOLUME IN THE RAT BRAIN. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2011;14(2):75-82. Available from: https://sid.ir/paper/81313/en

IEEE: Copy

MAHDIYE ASHEGHABADI, and MOHAMMAD REZA BIGDELI, “THE ROLE OF OXYGEN RADICALS-SCAVENGER IN NEUROPROTECTION-INDUCED BY NORMOBARIC HYPEROXIA ON INFARCT VOLUME IN THE RAT BRAIN,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 14, no. 2, pp. 75–82, 2011, [Online]. Available: https://sid.ir/paper/81313/en

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