A COMPARATIVE STUDY ON THE RADIOPROTECTIVE EFFECT OF CIMETIDINE AND FAMOTIDINE AGAINST GAMMA RAYS IN BONE MARROW CELLS

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EBRAHIMI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Physiology and Pharmacology Year:2001 | Volume:5 | Issue:1 Page(s): 13-26

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Title

A COMPARATIVE STUDY ON THE RADIOPROTECTIVE EFFECT OF CIMETIDINE AND FAMOTIDINE AGAINST GAMMA RAYS IN BONE MARROW CELLS

Author(s)

EBRAHIMI M. | Issue Writer Certificate

Keywords

RADIOPROTECTIVE AGENTSQ4

CIMETIDINEQ4

FAMOTIDINEQ4

BONE MARROWQ3

MOUSEQ4

MICRONUCLEI ASSAYQ4

Abstract

Previous investigations have shown that CIMETIDINE has radioprotective effect against gamma radiation. Since FAMOTIDINE like CIMETIDINE is a H2-receptorantagonist, therefore in this study the radioprotective effect of CIMETIDINE and FAMOTIDINE against gamma rays-induced micronuclei was tested in BONE MARROW cells of 8 weeks-old male Balb/c MOUSE. CIMETIDINE at doses of 7.5, 15 and 30 mg/Kg and FAMOTIDINE at doses of 0.75, 1.5 and 3 mg/Kg was injected (i.p.) alone or 2 hours before gamma rays exposure. For both groups frequency of MNPCE and MNNCE and the ratio of PCE/PCE+NCE were determined 24 hours after the drug treatments and/or gamma irradiation of mice. After exposure of mice to 2 Gy gamma rays, the frequency of MNPCE increased significantly (P<0.0001) and the ratio of PCE/PCE+NCE was decreased (P<0.0001) compared to control group. Results showed that the drugs given alone with no subsequent gamma irradiation had no effect on the frequency of MNPCE and the ratio of PCE/PCE+NCE in comparison to control group (P<0.05). In addition, CIMETIDINE and FAMOTIDINE administered prior to gamma irradiation resulted in a reduction of frequency of MNPCE (P<0.001) in comparison to gamma-irradiated group, but FAMOTIDINE produced a stronger effect than CIMETIDINE (P<0.05). Furthermore, CIMETIDINE increased the ratio of PCE/PCE+NCE (P<0.05), but FAMOTIDINE had no effect in this respect. It is also concluded that the radioprotective effect of the drugs was also dose-dependent.

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APA: Copy

EBRAHIMI, M.,. (2001). A COMPARATIVE STUDY ON THE RADIOPROTECTIVE EFFECT OF CIMETIDINE AND FAMOTIDINE AGAINST GAMMA RAYS IN BONE MARROW CELLS. PHYSIOLOGY AND PHARMACOLOGY, 5(1), 13-26. SID. https://sid.ir/paper/75250/en

Vancouver: Copy

EBRAHIMI M.. A COMPARATIVE STUDY ON THE RADIOPROTECTIVE EFFECT OF CIMETIDINE AND FAMOTIDINE AGAINST GAMMA RAYS IN BONE MARROW CELLS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2001;5(1):13-26. Available from: https://sid.ir/paper/75250/en

IEEE: Copy

M. EBRAHIMI, an, “A COMPARATIVE STUDY ON THE RADIOPROTECTIVE EFFECT OF CIMETIDINE AND FAMOTIDINE AGAINST GAMMA RAYS IN BONE MARROW CELLS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 5, no. 1, pp. 13–26, 2001, [Online]. Available: https://sid.ir/paper/75250/en

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