THE EFFECT OF INTRAGASTRIC D-GLUCOSE ON HYPERACIDITY INDUCED BY HISTAMINE AND CARBACHOL IN MALE RAT

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ELIASI A.; MAJD SH.; ELYASI H.A.

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Paper Information

Journal: Physiology and Pharmacology Year:2001 | Volume:5 | Issue:1 Page(s): 35-42

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Title

THE EFFECT OF INTRAGASTRIC D-GLUCOSE ON HYPERACIDITY INDUCED BY HISTAMINE AND CARBACHOL IN MALE RAT

Author(s)

ELIASI A. | MAJD SH. | ELYASI H.A. | Issue Writer Certificate

Keywords

INTRAGASTRIC D-GLUCOSEQ4

CARBACHOLQ4

HISTAMINEQ4

GASTRIC ACIDQ4

Abstract

It has been shown that enhanced acid secretion can be suppressed in the rat by systemic administration of glucose. We have recently reported that enhancement of acid secretion as a result of pentagastrin was diminished by intragastric administration of D-glucose.Present study was designed to investigate whether INTRAGASTRIC D-GLUCOSE influences GASTRIC ACID secretion associated with CARBACHOL and HISTAMINE in rat, and then we compared these results with our previous results obtained by pentagastrin-induced hyperacidity.Intravenous infusion of CARBACHOL (1 mg/100 g/h) and HISTAMINE (0.5 mg/100 g/h) caused an immediate increase in acid secretion with a peak starting after 40 and 60 min and then reached to a steady state respectively. lntragastric administration of D-glucose significantly reduced the hyperacidity induced by HISTAMINE and CARBACHOL (P<0.01). The effect of INTRAGASTRIC D-GLUCOSE On hyperacidity induced by pentagastrin or HISTAMINE when compared with CARBACHOL-induced hyperacidity was significantly greater than CARBACHOL group.In conclusion, it is suggested that the inhibitory effect of INTRAGASTRIC D-GLUCOSE observed in hyperacidity may be the result of glucose-induced modification of intragastric pathways in parietal cells that control GASTRIC ACID secretion.

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References

SURVEYING THE EFFECT OF INTRA GASTRIC ADMINISTRATION OF D-GLUCOSE ON HYPERACIDITY DUE TO PENTAGASTRIN IN RAT

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APA: Copy

ELIASI, A., MAJD, SH., & ELYASI, H.A.. (2001). THE EFFECT OF INTRAGASTRIC D-GLUCOSE ON HYPERACIDITY INDUCED BY HISTAMINE AND CARBACHOL IN MALE RAT. PHYSIOLOGY AND PHARMACOLOGY, 5(1), 35-42. SID. https://sid.ir/paper/75252/en

Vancouver: Copy

ELIASI A., MAJD SH., ELYASI H.A.. THE EFFECT OF INTRAGASTRIC D-GLUCOSE ON HYPERACIDITY INDUCED BY HISTAMINE AND CARBACHOL IN MALE RAT. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2001;5(1):35-42. Available from: https://sid.ir/paper/75252/en

IEEE: Copy

A. ELIASI, SH. MAJD, and H.A. ELYASI, “THE EFFECT OF INTRAGASTRIC D-GLUCOSE ON HYPERACIDITY INDUCED BY HISTAMINE AND CARBACHOL IN MALE RAT,” PHYSIOLOGY AND PHARMACOLOGY, vol. 5, no. 1, pp. 35–42, 2001, [Online]. Available: https://sid.ir/paper/75252/en

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