SURVEYING THE EFFECT OF INTRA GASTRIC ADMINISTRATION OF D-GLUCOSE ON HYPERACIDITY DUE TO PENTAGASTRIN IN RAT

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ELIASI A.; MAJD SH.; ELIASI H.

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Journal: Researcher Bulletin of Medical Sciences Year:2001 | Volume:6 | Issue:2 (22) Page(s): 111-116

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Title

SURVEYING THE EFFECT OF INTRA GASTRIC ADMINISTRATION OF D-GLUCOSE ON HYPERACIDITY DUE TO PENTAGASTRIN IN RAT

Author(s)

ELIASI A. | MAJD SH. | ELIASI H. | Issue Writer Certificate

Keywords

GASTRIC ACIDQ4

D-GLUCOSEQ4

PENTAGASTRINQ4

Abstract

Background: Peptic ulcer is among the most common diseases of GI tract in which hyperacidity occurs. Several evidences have confessed the inhibitory effects of systemic glucose administration on hyperacidity in rats and dogs. this study was conducted with the aim of investigating the effects of intragastric administration D-gducoseon hyperacidity output in anesthetized rats.Materials and methods: 84 male rats in groups of 6 have entered our experimental study. For intragastric administration of different solutions, a polyethylenic tube was applied through esophagus, however, gastric contents were sent out via a plastic cannula. GASTRIC ACIDity was evaluated by base titration and results were reported as mEq/10 min. T-test, paired Hest, and ANOVA analyzed the obtained results. Results: Intravenous infusion of PENTAGASTRIN (mg/100g/hr) induced marked increase in GASTRIC ACID secretion (GAS) with a peak starting at 30th minute. Results have revealed that enhanced acid secretion was diminished applying 20mM D-GLUCOSE intragastrically. (48%±4.7) Washing glucose out reversed this effect of D-GLUCOSE. Different osmolality of glucose solution plays no role in decreasing GAS, meanwhile, no change in plasma glucose concentration was seen.Conclusion: intragastrically administration of D-GLUCOSE (without entering intestine or blood) has an apparently inhibitory effect on GAS, where altered glucose modification of intracellular pathways controlling GAS Seems to be the effective mechanism.

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APA: Copy

ELIASI, A., MAJD, SH., & ELIASI, H.. (2001). SURVEYING THE EFFECT OF INTRA GASTRIC ADMINISTRATION OF D-GLUCOSE ON HYPERACIDITY DUE TO PENTAGASTRIN IN RAT. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 6(2 (22)), 111-116. SID. https://sid.ir/paper/18402/en

Vancouver: Copy

ELIASI A., MAJD SH., ELIASI H.. SURVEYING THE EFFECT OF INTRA GASTRIC ADMINISTRATION OF D-GLUCOSE ON HYPERACIDITY DUE TO PENTAGASTRIN IN RAT. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2001;6(2 (22)):111-116. Available from: https://sid.ir/paper/18402/en

IEEE: Copy

A. ELIASI, SH. MAJD, and H. ELIASI, “SURVEYING THE EFFECT OF INTRA GASTRIC ADMINISTRATION OF D-GLUCOSE ON HYPERACIDITY DUE TO PENTAGASTRIN IN RAT,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 6, no. 2 (22), pp. 111–116, 2001, [Online]. Available: https://sid.ir/paper/18402/en

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