EFFECT OF DIFFERENT FREQUENCIES OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) ON ACQUISITION OF CHEMICAL KINDLING SEIZURES IN RATS

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MONGABADI S.; FIROUZABADI S.M.; MIRNAJAFIZADEH S.J.

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Journal: Physiology and Pharmacology Year:2008 | Volume:12 | Issue:1 Page(s): 31-38

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Title

EFFECT OF DIFFERENT FREQUENCIES OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) ON ACQUISITION OF CHEMICAL KINDLING SEIZURES IN RATS

Author(s)

MONGABADI S. | FIROUZABADI S.M. | MIRNAJAFIZADEH S.J. | Issue Writer Certificate

Keywords

RTMSQ3

EPILEPSYQ3

SEIZUREQ3

PENTHYLENTERAZOLQ2

CHEMICAL KINDLINGQ3

RATQ3

Abstract

Introduction: Repetitive transcranial magnetic stimulation (RTMS) modulates the excitability of cortical neural networks. The effect of RTMS on excitability of cortical networks depends on its frequency. According to the previous reports, a distinction is made between low «1 Hz) and high frequencies of RTMS. Low frequencies of RTMS inhibit SEIZURE but high frequencies increase it. In the current study, we tried to investigate the effect of different frequencies of RTMS on CHEMICAL KINDLING induced SEIZURE in RATs.Methods: CHEMICAL KINDLING was induced by i.p. injections of penthylentetrazol (PTZ) 45 mg/kg, 3 times per week. Effects of different frequencies of RTMS (0.25, 1 and 5 Hz) on kindling acquisition were investigated. RTMS was applied 30 minutes after PTZ injections. Stimulation was delivered at motor threshold intensity (4s, 4 stimulus interval of 10 s).Results: Maximum stage of behavioral SEIZURE decreased by 0.25 Hz RTMS and increased by 5 Hz RTMS. Stages 4 and 5 latencies were increased by 0.25 Hz RTMS and decreased by 5 Hz RTMS. Stage 5 duration was decreased by 0.25 Hz RTMS and increased by 5 Hz RTMS.Discussion: Our results showed that application of RTMS had significant effect on SEIZURE parameters in the acquisition period. Lower frequencies of RTMS seem to be more effective.

Cites

ASSESSING ANTICONVULSANT EFFECT OF AQUEOUS EXTRACT OF DATURA STRAMONIUM SEED ON PTZ-INDUCED SEIZURES IN THE MALE MICE

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APA: Copy

MONGABADI, S., FIROUZABADI, S.M., & MIRNAJAFIZADEH, S.J.. (2008). EFFECT OF DIFFERENT FREQUENCIES OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) ON ACQUISITION OF CHEMICAL KINDLING SEIZURES IN RATS. PHYSIOLOGY AND PHARMACOLOGY, 12(1), 31-38. SID. https://sid.ir/paper/75254/en

Vancouver: Copy

MONGABADI S., FIROUZABADI S.M., MIRNAJAFIZADEH S.J.. EFFECT OF DIFFERENT FREQUENCIES OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) ON ACQUISITION OF CHEMICAL KINDLING SEIZURES IN RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2008;12(1):31-38. Available from: https://sid.ir/paper/75254/en

IEEE: Copy

S. MONGABADI, S.M. FIROUZABADI, and S.J. MIRNAJAFIZADEH, “EFFECT OF DIFFERENT FREQUENCIES OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) ON ACQUISITION OF CHEMICAL KINDLING SEIZURES IN RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 12, no. 1, pp. 31–38, 2008, [Online]. Available: https://sid.ir/paper/75254/en

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