THE EFFECT OF BILATERAL INTRAHIPPOCAMPAL INJECTION OF ALL-TRANS RETINOIC ACID ON SPATIAL LEARNING IN ADULT MALE RATS

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AMINI ZADEH MAHMOUD; ABBASNEZHAD M.; MOAZEDI A.A.; PA PAHN A.A.

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Journal: Physiology and Pharmacology Year:2008 | Volume:12 | Issue:1 Page(s): 60-67

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Title

THE EFFECT OF BILATERAL INTRAHIPPOCAMPAL INJECTION OF ALL-TRANS RETINOIC ACID ON SPATIAL LEARNING IN ADULT MALE RATS

Author(s)

AMINI ZADEH MAHMOUD | ABBASNEZHAD M. | MOAZEDI A.A. | PA PAHN A.A. | Issue Writer Certificate

Keywords

ALL-TRAN'S RETINOIC ACIDQ3

SPATIALLEAMINGQ4

MORRIS WATER MAZEQ3

HIPPOCAMPUSQ3

Abstract

Introduction: Previous studies have shown that vitamin A and its derivatives such as retinoid and all-trans retinoic acid has a crucial role in memory, learning and synaptic plasticity. The receptors of vitamin A are seen in different parts of the brain such as HIPPOCAMPUS, where vitamin A has an important role in learning. In this study, the effect of intrahippocampal (CA1) injection of all-trans retinoic acid on spatial learning was investigated in adult male rats.Methods: 49 adult male rats divided in 7 groups were used. Test groups (1 -4) received 1 m of all-trans retinoic acid dissolved in DMSO at concentrations of 1, 2, 4 and 8 g/m for 4 consecutive days, 90 minutes before training. Group 5 received DMSO and 6th and 7th groups were designated as sham operation and control (intact) group, respectively. After each injection, MORRIS WATER MAZE (MWM) was used as a method to measure learning task. Results: This study showed that all -trans retinoic acid at the concentration of 1 g/m improved spatial learning in MORRIS WATER MAZE (p< 0.05).Conclusion: Our findings show that all -trans retinoic acid improves spatial learning in rats via enhancing the expression of learning related proteins.

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APA: Copy

AMINI ZADEH, MAHMOUD, ABBASNEZHAD, M., MOAZEDI, A.A., & PA PAHN, A.A.. (2008). THE EFFECT OF BILATERAL INTRAHIPPOCAMPAL INJECTION OF ALL-TRANS RETINOIC ACID ON SPATIAL LEARNING IN ADULT MALE RATS. PHYSIOLOGY AND PHARMACOLOGY, 12(1), 60-67. SID. https://sid.ir/paper/75262/en

Vancouver: Copy

AMINI ZADEH MAHMOUD, ABBASNEZHAD M., MOAZEDI A.A., PA PAHN A.A.. THE EFFECT OF BILATERAL INTRAHIPPOCAMPAL INJECTION OF ALL-TRANS RETINOIC ACID ON SPATIAL LEARNING IN ADULT MALE RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2008;12(1):60-67. Available from: https://sid.ir/paper/75262/en

IEEE: Copy

MAHMOUD AMINI ZADEH, M. ABBASNEZHAD, A.A. MOAZEDI, and A.A. PA PAHN, “THE EFFECT OF BILATERAL INTRAHIPPOCAMPAL INJECTION OF ALL-TRANS RETINOIC ACID ON SPATIAL LEARNING IN ADULT MALE RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 12, no. 1, pp. 60–67, 2008, [Online]. Available: https://sid.ir/paper/75262/en

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