Associations of Uncoupling Protein 2 Ala55Val and Uncoupling Protein 3-55C/T Polymorphisms with Heart Rate Variability in Young Oarsmen-a Pilot Study

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Melnikov Andrey Aleksandrovich; Bobylev Artem Sergeevich; Varfolomeeva Zoya Semenovna

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Journal: Asian Journal of Sports Medicine Year:2019 | Volume:10 | Issue:2 Page(s): 0-0

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Title

Associations of Uncoupling Protein 2 Ala55Val and Uncoupling Protein 3-55C/T Polymorphisms with Heart Rate Variability in Young Oarsmen-a Pilot Study

Author(s)

Melnikov Andrey Aleksandrovich | Bobylev Artem Sergeevich | Varfolomeeva Zoya Semenovna | Issue Writer Certificate

Keywords

UCP2 Ala55Val

UCP3-55T/S

Gene Polymorphisms

Heart Rate Variability

Athletes

Abstract

Background: Human heredity is known to determine about 50% of Heart Rate Variability (HRV) based on a twin study; however, genetic polymorphisms causing increased HRV in Athletes are not known. Objectives: This article is aimed at studying the associations of uncoupling protein 2 (UCP2) Ala55Val (rs660339) and UCP3-55C/T (rs1800849) polymorphisms with Heart Rate Variability (HRV) in trained oarsmen. Methods: HRVindices (standard deviations of NNintervals (SDNN), rootmeansquare of successive differences (RMSSD), HF, LF, VLF), stroke index and cardiac index of the young oarsmen (age 17. 6 1. 6 years old, n = 23) were determined by impedance cardiography method in the supine and standing positions. Themaximumoxygen consumption (VO2max) was examined with a rower ergometer by means of a gas analyzer. Polymorphisms of the UCP2 Ala55Val and the UCP3-55T/C were genotyped by polymerase chain reaction (PCR) method and length analysis of restriction products. Results: It was found that both polymorphisms were not associated with VO2max. The UCP2 Val/Val genotype compared to the combined variant (Ala/Ala + Ala/Val) containing the 55 Ala allele, as well as the UCP3 T/T genotype compared to the combined variant (C/T + C/C) containing the-55C allele were associated with low HR and increased HRV: SDNN, RMSSD and HF vagal indices in the supine position. Moreover, the Athletes with the UCP3-55T/T genotype had a pronounced increase in heart rate (ANOVA, P < 0. 001) and a decrease in stroke index (ANOVA, P = 0. 005) in response to active orthostasis compared to C/T and C/C genotypes. Conclusions: The UCP2 Val/Val and the UCP3 T/T genotypes may be genetic markers of increased HRV in the highly trained Athletes, suggesting an influence of these UCP2/UCP3 polymorphisms on autonomic cardiovascular regulation.

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APA: Copy

Melnikov, Andrey Aleksandrovich, Bobylev, Artem Sergeevich, & Varfolomeeva, Zoya Semenovna. (2019). Associations of Uncoupling Protein 2 Ala55Val and Uncoupling Protein 3-55C/T Polymorphisms with Heart Rate Variability in Young Oarsmen-a Pilot Study. ASIAN JOURNAL OF SPORTS MEDICINE, 10(2), 0-0. SID. https://sid.ir/paper/752669/en

Vancouver: Copy

Melnikov Andrey Aleksandrovich, Bobylev Artem Sergeevich, Varfolomeeva Zoya Semenovna. Associations of Uncoupling Protein 2 Ala55Val and Uncoupling Protein 3-55C/T Polymorphisms with Heart Rate Variability in Young Oarsmen-a Pilot Study. ASIAN JOURNAL OF SPORTS MEDICINE[Internet]. 2019;10(2):0-0. Available from: https://sid.ir/paper/752669/en

IEEE: Copy

Andrey Aleksandrovich Melnikov, Artem Sergeevich Bobylev, and Zoya Semenovna Varfolomeeva, “Associations of Uncoupling Protein 2 Ala55Val and Uncoupling Protein 3-55C/T Polymorphisms with Heart Rate Variability in Young Oarsmen-a Pilot Study,” ASIAN JOURNAL OF SPORTS MEDICINE, vol. 10, no. 2, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/752669/en

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