EFFECT OF ESOPHAGEAL DISTENSION ON GASTRIC SECRETIONS IN RAT AND THE POSSIBLE MECHANISM

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MARD S.A.; GHARIB NASERI MOHAMMAD KAZEM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2007 | Volume:11 | Issue:1 Page(s): 60-67

Download Full-Text

Persian Verion

View:

1,372

Download:

Cites:

Information Journal Paper

Title

EFFECT OF ESOPHAGEAL DISTENSION ON GASTRIC SECRETIONS IN RAT AND THE POSSIBLE MECHANISM

Author(s)

MARD S.A. | GHARIB NASERI MOHAMMAD KAZEM | Issue Writer Certificate

Keywords

ESOPHAGEAL DISTENSIONQ3

GASTRIC SECRETIONSQ3

RESERPINEQ3

VAGUS NERVEQ3

RATQ3

Abstract

Introduction: The effect of ESOPHAGEAL DISTENSION (ED) on gastric motility has been well documented, but a few investigations have been carried out on the effect of ED on gastric secretion. The aim of this study was to investigate the effect of ED on gastric acid and pepsin secretion and the mechanism(s) involved. Methods: Male adult Wistar RATs (200-240 g) were anesthetized with urethane (1.2 g/kg, i.p.) and underwent tracheostomy and laparotomy. A catheter was inserted in the stomach through duodenum for gastric distension and gastric washout. Esophagus was distended by a balloon (0.3 ml, 10 min). Gastric acid secretion was stimulated by gastric distension (by saline 1.5 ml/100 g of B.W.), pentagastrin (20 μg/kg, i.p.) or insulin (0.6 IU/kg, i.p.). Pepsin secretion was stimulated by carbachol (20 μg/kg, i.p.). Effects of cervical vagotomy and RESERPINE (1 mg/kg, i.p.) were also investigated. Results: Gastric distension-, pentagastrin- and insulin-stimulated gastric acid secretion were decreased by ESOPHAGEAL DISTENSION (P<0.001, P<0.05 and P<0.05, respectively). Carbachol-induced pepsin secretion was also attenuated by ESOPHAGEAL DISTENSION (P<0.05). Cervical vagotomy abolished the inhibitory effect of ED on gastric distension-induced acid secretion. In reserpinized RATs, ED reduced the basal gastric acid secretion (P<0.05). Conclusion: Results indicated that the ED decreased gastric acid output. The VAGUS NERVE was involved in the inhibitory effect of the ED on gastric acid secretion but the adrenergic system did not play role.

Cites

No record.

References

No record.

Cite

APA: Copy

MARD, S.A., & GHARIB NASERI, MOHAMMAD KAZEM. (2007). EFFECT OF ESOPHAGEAL DISTENSION ON GASTRIC SECRETIONS IN RAT AND THE POSSIBLE MECHANISM. PHYSIOLOGY AND PHARMACOLOGY, 11(1), 60-67. SID. https://sid.ir/paper/75272/en

Vancouver: Copy

MARD S.A., GHARIB NASERI MOHAMMAD KAZEM. EFFECT OF ESOPHAGEAL DISTENSION ON GASTRIC SECRETIONS IN RAT AND THE POSSIBLE MECHANISM. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2007;11(1):60-67. Available from: https://sid.ir/paper/75272/en

IEEE: Copy

S.A. MARD, and MOHAMMAD KAZEM GHARIB NASERI, “EFFECT OF ESOPHAGEAL DISTENSION ON GASTRIC SECRETIONS IN RAT AND THE POSSIBLE MECHANISM,” PHYSIOLOGY AND PHARMACOLOGY, vol. 11, no. 1, pp. 60–67, 2007, [Online]. Available: https://sid.ir/paper/75272/en

Related Journal Papers