EFFECTS OF REGULAR SWIMMING EXERCISE ON THE PAIN THRESHOLD FOLLOWING WITHDRAWAL SYNDROME IN MORPHINE-DEPENDENT RATS

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YADEGARI FARZANEH; HEIDARIANPOUR ALI; NAZEM FARZAD

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Journal: Physiology and Pharmacology Year:2011 | Volume:15 | Issue:2 Page(s): 289-294

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Title

EFFECTS OF REGULAR SWIMMING EXERCISE ON THE PAIN THRESHOLD FOLLOWING WITHDRAWAL SYNDROME IN MORPHINE-DEPENDENT RATS

Author(s)

YADEGARI FARZANEH | HEIDARIANPOUR ALI | NAZEM FARZAD | Issue Writer Certificate

Keywords

ADDICTIONQ3

MORPHINE SULFATEQ2

NALOXAN HYDROCHLORIDEQ2

NOCICEPTIVE THRESHOLDQ2

SWIMMING TRAININGQ2

Abstract

Introduction: Nowadays Opioids are gaining acceptance for the management of moderate to severe and chronic pain. In addition, a number of studies have shown that plasma levels of b-endorphin (bEP) in exercise trained are higher than sedentary rats. In our study we assume that exercise training can reduce pain after withdrawal syndrome in morphine-dependent rats.Methods: Male Wistar rats (250±20 g, N=24) were addicted by MORPHINE SULFATE 0.4mg/ml (for 21 days) and animals were submitted to SWIMMING TRAINING, five days a week for 8 weeks, in which First 60 minutes for 3 weeks and then 90 minutes in two weeks and at the end 120 min for 3weeks. At the end of each stage of exercise protocol NALOXAN HYDROCHLORIDE (3mg/kg.ip) was injected. Tail-flick was used to assess the effect of training on NOCICEPTIVE THRESHOLD.Results: Data showed that swimming aerobic exercise significantly increased pain threshold in trained control and addicted rats (p<0.05) while pain responses did not significantly change in sedentary control and addicted rats.Conclusion: Our results indicate that SWIMMING TRAINING has analgesic property in morphine withdrawal-induced hyperalgesia in rats. Therefore, it can be used for the treatment and/or management of painful conditions.

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APA: Copy

YADEGARI, FARZANEH, HEIDARIANPOUR, ALI, & NAZEM, FARZAD. (2011). EFFECTS OF REGULAR SWIMMING EXERCISE ON THE PAIN THRESHOLD FOLLOWING WITHDRAWAL SYNDROME IN MORPHINE-DEPENDENT RATS. PHYSIOLOGY AND PHARMACOLOGY, 15(2), 289-294. SID. https://sid.ir/paper/75299/en

Vancouver: Copy

YADEGARI FARZANEH, HEIDARIANPOUR ALI, NAZEM FARZAD. EFFECTS OF REGULAR SWIMMING EXERCISE ON THE PAIN THRESHOLD FOLLOWING WITHDRAWAL SYNDROME IN MORPHINE-DEPENDENT RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2011;15(2):289-294. Available from: https://sid.ir/paper/75299/en

IEEE: Copy

FARZANEH YADEGARI, ALI HEIDARIANPOUR, and FARZAD NAZEM, “EFFECTS OF REGULAR SWIMMING EXERCISE ON THE PAIN THRESHOLD FOLLOWING WITHDRAWAL SYNDROME IN MORPHINE-DEPENDENT RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 15, no. 2, pp. 289–294, 2011, [Online]. Available: https://sid.ir/paper/75299/en

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